Uracil

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Names

[ CAS No. ]:
66-22-8

[ Name ]:
Uracil

[Synonym ]:
Uracll
Ura
EINECS 200-621-9
Dihydro-pyrimidine-2,4-dione
3,4-Dihydrouracil
2,4(1H,3H)-Pyrimidinedione
Urasil
2,4-Dioxotetrahydropyrimidine
pyrimidine-2,4-diol
2,4-dioxo-3,4-dihydropyrimidin
Pirod
hybarx
pyrimidine-2,4(1H,3H)-dione
Uracil
Pyrod
MFCD00006016
2,4-DIHYDROXY PYRIMIDINE
Lamivudine Impurity 6

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
440.5±37.0 °C at 760 mmHg

[ Melting Point ]:
330°C

[ Molecular Formula ]:
C₄H₄N₂O₂

[ Molecular Weight ]:
112.087

[ Flash Point ]:
220.2±26.5 °C

[ Exact Mass ]:
112.027275

[ PSA ]:
65.72000

[ LogP ]:
-2.55

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.640

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
SOLUBLE IN HOT WATER

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ8650000

CHEMICAL NAME :: Uracil

CAS REGISTRY NUMBER :: 66-22-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C4-H4-N2-O2

MOLECULAR WEIGHT :: 112.10

WISWESSER LINE NOTATION :: T6MVMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1513 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 131 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1905 gm/kg/96W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 378 gm/kg/30W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 454 gm/kg/36W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 235 gm/kg/20W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 189 gm/kg/15W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 18 gm/kg

SEX/DURATION :: female 17-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15400 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 616 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - sex ratio

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

REFERENCE :: NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 19,40,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9246 No. of Facilities: 737 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 5593 (estimated) No. of Female Employees: 2969 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
YQ8650000

[ Hazard Class ]:
4.2

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Thiouracil
Methyl 3,3-dimethoxypropionate
2'-deoxyuridine
Guanine
Trifluorothymine
5-Bromouracil
5-Iodouracil
(E)-4,4,4-TRIFLUORO-1-PHENYL-BUT-2-EN-1-ONE
2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl methanesulfonate
[1-(4-isopropoxypyrimidin-2-yl)piperidin-2-yl]-methanol

DownStream

1,3-bis(ethenyl)pyrimidine-2,4-dione
2,4-Dimethoxypyrimidine
2,4-Dichloropyrimidine
Chloroform
Dichloroacetonitrile
Cyanogen chloride
uridine triacetate
1-aminopyrimidine-2,4-dione

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use.

J. Pharm. Biomed. Anal. 98 , 446-62, (2014)

The purpose of the study was to investigate the degradation pathway of 5-fluorouracil (FU) in the situation of commercial formulations for clinical use, namely FU dissolved in sodium hydroxide (NaOH) ...

The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer.

Cancer Epidemiol. Biomarkers Prev. 23(11) , 2328-37, (2014)

Although colorectal cancer is a disease characterized by sequential accumulation of mutations in epithelial cells, mechanisms leading to genomic vulnerability contributing to tumor initiation remain u...

Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase.

Biochem. Biophys. Res. Commun. 453(3) , 642-7, (2014)

When mRNAs lack stop codons, errors in gene expression and coding of aberrant proteins that are harmful in cells can result. In Saccharomyces cerevisiae, a 180-kDa E3-ubiquitin ligase, Ltn1 has been k...

Uracil-6T
Uracil-d2
uracil-d4
Uracil-d1
BV uracil
THIURACIL
N-(butan-2-yl)isoquinolin-5-amine
4-(Methylamino)pyridine-2-carboxamide
4-(Butylamino)picolinamide
N-(cyclopropylmethyl)isoquinolin-5-amine
4-Chloro-2-(pentylamino)benzonitrile
4-(4-Amino-2-chlorophenoxy)picolinamide
2-Pyridinecarboxamide, 4-[4-(hydroxyimino)-1-piperidinyl]-N-methyl-
4-Amino-N-methylpyridine-2-carboxamide
4-(2-amino-5-methylphenoxy)-N-methylpyridine-2-carboxamide
4-(4-amino-2-fluorophenoxy)-N-methylpyridine-2-carboxamide

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