2-Naphthaldehyde

Names

[ CAS No. ]:
66-99-9

[ Name ]:
2-Naphthaldehyde

[Synonym ]:
naphthalene-2-carbaldehyde
EINECS 200-640-2
Naphthalen-2-carbaldehyd
MFCD00004094
2-Naphthalenecarboxaldehyde
2-Naphthaldehyde
2-Naphthalenecarboxaldehyde (9CI)
β-Formylnaphthalene

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
299.5±9.0 °C at 760 mmHg

[ Melting Point ]:
58-61 °C(lit.)

[ Molecular Formula ]:
C₁₁H₈O

[ Molecular Weight ]:
156.181

[ Flash Point ]:
179.5±5.0 °C

[ Exact Mass ]:
156.057510

[ PSA ]:
17.07000

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.676

[ Storage condition ]:
?20°C

[ Freezing Point ]:
1.0755

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ0190010

CHEMICAL NAME :: 2-Naphthaldehyde

CAS REGISTRY NUMBER :: 66-99-9

BEILSTEIN REFERENCE NO. :: 0507750

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H8-O

MOLECULAR WEIGHT :: 156.19

WISWESSER LINE NOTATION :: L66J CVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 19,964,1964

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN 3335

[ WGK Germany ]:
3

[ RTECS ]:
QJ0190010

[ Packaging Group ]:
I; II; III

[ HS Code ]:
29122900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Naphthalenemethanol
2-naphthalen-2-yl-1,3-dithiane
2-naphthoic chloride
2-Naphthoic acid
acetic acid,naphthalen-2-ylmethanediol
2-Vinylnaphthalene
2-(brommethyl)naphthalen
2-Bromonaphthalene
carbon monoxide
2-Naphthyl trifluoromethanesulfonate

DownStream

AKOS B018336
diethoxyphosphoryl(naphthalen-2-yl)methanol
2-Methyl-1,2'-dinaphthyl Ketone
Fmoc-(R)-3-Amino-3-(2-naphthyl)-propionic acid
Amino(2-naphthyl)acetic acid
3-hydroxy-2-methyl-3-(naphthalen-2-yl)-1-phenylpropan-1-one
Phenyl ethyl ketone
2-naphthalen-2-yl-1,3-benzoxazole
5-naphthalen-2-yl-1,3-oxazole
2-Methyl-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one

Customs

[ HS Code ]: 2912299000

[ Summary ]:
2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism.

Contraception 33(5) , 519-28, (1986)

Gossypol tetramethyl ether [C30 H24 O2(OCH3)4] and gossypol hexamethyl ether [C30 H24 O2(OCH3)6], which in contrast to gossypol are stable compounds, were tested for their ability to depress fructose ...

Naphthaldehydes as reversible inhibitors of rat hepatic aryl sulfotransferase IV (tyrosine-ester sulfotransferase).

Drug Metab. Dispos. 21(2) , 400-2, (1993)

pH-Responsive polymeric micelles based on amphiphilic chitosan derivatives: Effect of hydrophobic cores on oral meloxicam delivery.

Int. J. Pharm. 497 , 150-60, (2016)

The amphiphilic chitosan derivatives, N-naphthyl-N,O-succinyl chitosan (NSCS), N-octyl-N-O-succinyl chitosan (OSCS) and N-benzyl-N,O-succinyl chitosan (BSCS), were synthesized. Meloxicam (MX) was load...