Saframycin A

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Names

[ CAS No. ]:
66082-27-7

[ Name ]:
Saframycin A

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Molecular Formula ]:
C29H30N4O8

[ Molecular Weight ]:
562.57000

[ Exact Mass ]:
562.20600

[ PSA ]:
163.18000

[ LogP ]:
0.11728

[ Index of Refraction ]:
1.632

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VN2265000
CHEMICAL NAME :
Saframycin A
CAS REGISTRY NUMBER :
66082-27-7
LAST UPDATED :
199403
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C29-H30-N4-O8
MOLECULAR WEIGHT :
562.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4900 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3300 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
160 ug/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

Related Compounds

  • Saframycin AH2
  • Decyano-saframycin A
  • 14-Hydroxysaframycin A
  • Saframycin R
  • Benz[a]indeno[1,2,3-de]naphthacene
  • 2-a]pyrazine-6-carbonitrile
  • Carbamic acid, (4-methyl-3-(((2-methyl-1-aziridinyl)carbonyl)amino)phenyl)-, 2-((3,3,4,4,5,5,6,6,7,7,8,8,9,10,10,10-hexadecafluoro-9-(trifluoromethyl)decyl)thio)-1-(((3,3,4,4,5,5,6,6,7,7,8,8,9,10,10,10-hexadecafluoro-9-(trifluoromethyl)decyl)thio)methyl)ethyl ester
  • Nickel(1+), [1-[2-amino-4-(imino-kappaN)-5(4H)-thiazolylidene]-N-[1-[2-amino-4-(imino-kappaN)-5(4H)-thiazolylidene]-1H-isoindol-3-yl-kappaN]-1H-isoindol-3-aminato-kappaN2]-, chloride
  • Naja melanoleuca toxin V(sup II) 3
  • ((1,2-Ethanediylbis(carbamodithioato))(2-))manganese mixt. with 1-(8-hydroxy-5-quinolinyl)ethanone, sulfate (2:1) (salt)
  • Hexadecaaluminium barium dimagnesium heptacosaoxide
  • Trisodium bis(3-((4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo)-2-hydroxy-5-nitrobenzenesulphonato(3-))chromate(3-)
  • Citrimycin
  • Calcitonin (human), trihydrochloride
  • Dimethylammonium borodisalicylate
  • Antibiotic 67-121B
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