GW843682X

Suppliers

Names

[ Name ]:
GW843682X

[Synonym ]:
thiophene deriv.,20
Kinome_3462
GW 843682X
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{2-[2-(trifluoromethyl)phenyl]ethoxy}-2-thiophenecarboxamide
2-Thiophenecarboxamide, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[2-[2-(trifluoromethyl)phenyl]ethoxy]-
GW843682X

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
629.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₁₈F₃N₃O₄S

[ Molecular Weight ]:
477.46

[ Flash Point ]:
334.6±34.3 °C

[ PSA ]:
116.84000

[ LogP ]:
4.25

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.613

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H413

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

Articles

Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy.

Cell Cycle 14(3) , 399-407, (2015)

The mechanistic target of rapamycin complex 1 (mTORC1) increases translation, cell size and angiogenesis, and inhibits autophagy. mTORC1 is negatively regulated by hamartin and tuberin, the protein pr...

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

Mol. Cancer Ther. 6 , 450-459, (2007)

Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation, and cytokinesis. PLK1 expression and activity ar...

2-methyl-1-(phenylsulfonyl)-4-[4-(1-pyrrolidinylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridine
4-methyl-1-(pyrimidin-5-yl)-1H-pyrazole-3-carboxylic acid
2-Piperidinepropanamide, N-[1-(4-chlorophenyl)ethyl]-N-methyl-
{1-[(3-Chloro-2-fluorophenyl)methyl]cyclopropyl}methanamine
4-Ethyloxolan-3-ol
6-Methylspiro[1,2-dihydroindene-3,2'-cyclopropane]-1'-carboxylic acid
(2,4-Difluorophenyl)(3-(hydroxymethyl)pyrrolidin-1-yl)methanone
2-{[(3,4-Dihydroxyphenyl)methyl]amino}-3-methylbutanamide
tert-butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate hydrochloride
Benzyl methyl(1,4-dioxaspiro[4.5]decan-8-yl)carbamate

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