4-Methylthiosemicarbazide

Names

[ Name ]:
4-Methylthiosemicarbazide

[Synonym ]:
N-Methylhydrazinecarbothioamide
1-amino-3-methylthiourea
MFCD00007617
N-methyl-thiosemicarbazide
EINECS 229-563-2
Hydrazinecarbothioamide, N-methyl-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
168.4±23.0 °C at 760 mmHg

[ Melting Point ]:
135-138 °C(lit.)

[ Molecular Formula ]:
C₂H₇N₃S

[ Molecular Weight ]:
105.162

[ Flash Point ]:
55.6±22.6 °C

[ Exact Mass ]:
105.036064

[ PSA ]:
82.17000

[ LogP ]:
-0.82

[ Vapour Pressure ]:
1.6±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
Poison room

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MV1407370

CHEMICAL NAME :: Hydrazinecarbothioamide, N-methyl-

CAS REGISTRY NUMBER :: 6610-29-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C2-H7-N3-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571100

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300

[ Precautionary Statements ]:
P264-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R28

[ Safety Phrases ]:
S45-S28A-S1

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
MV1407370

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methyl isothiocyanate
Carbon disulphide
methylamine
hydrogen sulfide
Methyl Hydrazinecarbodithioate
methyldithiocarbamic acid
Carbamodithioic acid,methyl-, methyl ester (9CI)

DownStream

4-METHYL-5-(TRIFLUOROMETHYL)-4H-1,2,4-TRIAZOLINE-3(2H)-THIONE
3H-1,2,4-Triazole-3-thione,2,4-dihydro-4,5-dimethyl-
5-BENZYL-4-METHYL-4H-1,2,4-TRIAZOLE-3-THIOL
4-Methyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-thiol
Pyridine chlorhydrate
Hydrazinecarbothioamide,N-methyl-2-(phenylmethylene)-
Hydrazinecarbothioamide,2-(diphenylmethylene)-N-methyl-
6-Thia-2,3,9,10,12-pentaazatrideca-3,8-dienethioamide,N-methyl-11-thioxo-
2-methylamino-5-mercapto-1,3,4-thiadiazole

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Electronic features and hydrogen bonding capacity of the sulfur acceptor in thioureido-based compounds. Experimental charge density study of 4-methyl-3-thiosemicarbazide. Francuski BM, et al., DOI: 10.1039/C0CE00760A

CrystEngComm 13 , 3580-3591, (2011)

1--4-methylthiosemicarbazide
4-benzyl-4-methylthiosemicarbazide
NICOTINOYL 4-METHYLTHIOSEMICARBAZIDE
1-Pivaloyl-4-methylthiosemicarbazide
1-(2-Thenoyl)-4-methylthiosemicarbazide
1-trifluoroacetyl-4-methylthiosemicarbazide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
6-(4-Benzyloxyphenyl)picolinic acid
3-(3-Fluoro-5-methoxycarbonylphenyl)picolinic acid
{5-[(4-methylpiperidin-1-yl)methyl]-1{H}-tetrazol-1-yl}acetic acid
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde