1-phenoxy-3-(4-phenylpiperazin-1-yl)propan-2-ol

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Names

[ CAS No. ]:
66307-43-5

[ Name ]:
1-phenoxy-3-(4-phenylpiperazin-1-yl)propan-2-ol

[Synonym ]:
1-phenoxy-3-(4-phenyl-piperazino)-propan-2-ol
1-phenoxy-3-(4-phenyl-piperazin-1-yl)-propan-2-ol

Chemical & Physical Properties

[ Density]:
1.143g/cm3

[ Boiling Point ]:
498ºC at 760 mmHg

[ Molecular Formula ]:
C19H24N2O2

[ Molecular Weight ]:
312.40600

[ Flash Point ]:
255ºC

[ Exact Mass ]:
312.18400

[ PSA ]:
35.94000

[ LogP ]:
2.25140

[ Index of Refraction ]:
1.586

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL9415000
CHEMICAL NAME :
1-Piperazineethanol, alpha-phenoxymethyl-4-phenyl-
CAS REGISTRY NUMBER :
66307-43-5
LAST UPDATED :
199012
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H23-N2-O2
MOLECULAR WEIGHT :
311.44
WISWESSER LINE NOTATION :
T6N DNTJ AY1Q1OR& DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,241,1978

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Phenylpiperazine
  • phenyl glycidyl ether
  • Epichlorohydrin
  • Phenol

DownStream

Related Compounds

  • 1-[2-(1-hydroxyethyl)phenoxy]-3-(4-phenylpiperazin-1-yl)propan-2-ol
  • 1-[4-[2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy]phenyl]-1-propanol
  • 1-phenoxy-3-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]propan-2-ol dihydrochloride
  • 1-(3-nitrophenoxy)-3-(4-phenylpiperazin-1-yl)propan-2-ol
  • 1-(3-methylphenoxy)-3-(4-phenylpiperazin-1-yl)propan-2-ol
  • 1-(4-nitrophenoxy)-3-(4-phenylpiperazin-1-yl)propan-2-ol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 2-{[(Benzyloxy)carbonyl]amino}-5-phenylthiophene-3-carboxylic acid
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide