Ratic

Suppliers

Names

[ CAS No. ]:
66357-35-5

[ Name ]:
Ratic

[Synonym ]:
Taural
Sostril
Terposen
Trigger
U1tidine
Ranitidine
Zantic
MFCD00081180
RANITIDINE USP
EINECS 266-332-5
U1cex
Zantae

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
437.1±45.0 °C at 760 mmHg

[ Melting Point ]:
69-70°C

[ Molecular Formula ]:
C13H22N4O3S

[ Molecular Weight ]:
314.404

[ Flash Point ]:
218.2±28.7 °C

[ Exact Mass ]:
314.141266

[ PSA ]:
111.56000

[ LogP ]:
1.23

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.559

[ Storage condition ]:
Desiccate at +4°C

[ Water Solubility ]:
24.7 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM6556500
CHEMICAL NAME :
1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)th io)ethyl)-N'-methyl- 2-nitro-
CAS REGISTRY NUMBER :
66357-35-5
LAST UPDATED :
199703
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C13-H22-N4-O3-S
MOLECULAR WEIGHT :
314.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
12 mg/kg/2D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis Blood - other changes Skin and Appendages - dermatitis, allergic (after topical exposure)
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 12,67,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2018 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
884 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 25,749,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
2

[ RTECS ]:
KM6557000

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

  • 2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine
  • Carbon
  • 1-nitro-2,2-bis(methylthio)ethylene
  • N-methyl-N'-(2-[(5-dimethylaminomethyl)-furan-2-ylmethylthio]-ethyl)-urea
  • nitromethane

DownStream

  • Ranitidine hydrochloride
  • [5-[(dimethylamino)methyl]furan-2-yl]methanol
  • (6Z)-6-[[5-[(dimethylamino)methyl]furan-2-yl]methoxyimino]-N-methyl-2,3-dihydro-1,4-thiazin-5-amine
  • 5,6-Dihydro-3-(methylamino)-2H-1,4-thiazin-2-one Oxime Hydrochloride
  • N,N-dimethyl-5-(2(1-methylamino-2-(5-dimethylaminomethyl-2-furfuryl)-2-nitrovinylamino)ethyl-thiomethyl)furfurylamine

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%