2-chlorpyridin-3-ol

Names

[ Name ]:
2-chlorpyridin-3-ol

[Synonym ]:
2-chloropyridin-3-ol
2-Chloro-3-pyridinol
EINECS 229-635-3
2-chlorpyridin-3-ol
3-Pyridinol, 2-chloro-
MFCD00006235

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
316.2±22.0 °C at 760 mmHg

[ Melting Point ]:
170-172 °C(lit.)

[ Molecular Formula ]:
C₅H₄ClNO

[ Molecular Weight ]:
129.54

[ Flash Point ]:
145.0±22.3 °C

[ Exact Mass ]:
128.998138

[ PSA ]:
33.12000

[ LogP ]:
1.27

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU7707000

CHEMICAL NAME :: 3-Pyridinol, 2-chloro-

CAS REGISTRY NUMBER :: 6636-78-8

BEILSTEIN REFERENCE NO. :: 0002216

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H4-Cl-N-O

MOLECULAR WEIGHT :: 129.55

WISWESSER LINE NOTATION :: T6NJ BG CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04685

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S37/39-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UU7707000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Chloro-3-pyridylboronic acid
2-Chloropyridine-3-boronic acid pinacol ester
2-Chloropyridine
Pyridin-3-ol
2-Bromo-3-ethoxypyridine
2-Chlorpyridin-3-amin
2-Nitro-3-pyridinol
2-nitro-1-oxy-pyridin-3-ol
3-Pyridinol 1-oxide

DownStream

2-CHLORO-3-BENZYLOXYMETHYLPYRIDINE
2,6-Dichloropyridin-3-ol
2-Chloro-4-nitro-3-pyridinol
Furo[2,3-c]pyridin-5-ylmethanol
Furo[2,3-c]pyridine-5-carboxylic acid
2-Chloro-6-methoxy-4-[2-(trimethylsilyl)ethynyl]-3-pyridinol
2-Phenylfuro[3,2-b]pyridine
2-Chloro-6-(hydroxymethyl)-3-pyridinol
2-Chloro-6-(hydroxymethyl)-4-iodo-3-pyridinol
5,6-Dimethoxynicotinaldehyde

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Novel heterocyclic systems. Part 21. Synthesis of 3-hydroxypyridine-2 (1H)-selone and its application in the synthesis of 1-azaphenoxaselenine and its substituted derivatives. Smith K, et al.

J. Chem. Soc. Perkin Trans. I , 2075-2079, (1986)

A concise synthesis of all four possible benzo[4,5]furopyridines via palladium-mediated reactions.

Org. Lett. 4(13) , 2201-3, (2002)

[reaction: see text] By taking advantage of the alpha- and gamma-activation of chloropyridines as well as palladium-mediated reactions, all four possible benzo[4,5]furopyridine tricyclic heterocycles,...

2-Chloro-5-hydroxypyridine
2-ethoxyoxan-3-ol
2-iodpyridin-3-ol
2-HEPTNE-3-OL,4,5-DIMETHYL-
2-methyloxolan-3-ol
2-Chloroquinolin-3-ol
2-fluoro-N,N-dimethyl-4-(1-methylpiperazin-2-yl)aniline
2-[2-(Methoxymethyl)-1,3-thiazol-4-yl]cyclopropan-1-amine
3-Amino-2-methyl-2-(2-methylpyridin-3-yl)propan-1-ol
3-(6-Methoxy-5-methylpyridin-3-yl)-3-methylbutanoic acid
3-[(1H-indazol-7-yl)methyl]azetidin-3-ol
(1R)-1-{3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl}ethan-1-amine
{3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl}methanol
4-amino-1-(1-methyl-1H-pyrazol-3-yl)cyclohexane-1-carboxylic acid
5-[2-(methoxymethyl)oxan-2-yl]-1-methyl-1H-pyrazol-4-amine
5-[2-(Methoxymethyl)oxan-2-yl]-1,2-oxazole-3-carboxylic acid

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