2-chlorpyridin-3-ol

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Names

[ CAS No. ]:
6636-78-8

[ Name ]:
2-chlorpyridin-3-ol

[Synonym ]:
2-chloropyridin-3-ol
2-Chloro-3-pyridinol
EINECS 229-635-3
2-chlorpyridin-3-ol
3-Pyridinol, 2-chloro-
MFCD00006235

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
316.2±22.0 °C at 760 mmHg

[ Melting Point ]:
170-172 °C(lit.)

[ Molecular Formula ]:
C5H4ClNO

[ Molecular Weight ]:
129.54

[ Flash Point ]:
145.0±22.3 °C

[ Exact Mass ]:
128.998138

[ PSA ]:
33.12000

[ LogP ]:
1.27

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU7707000
CHEMICAL NAME :
3-Pyridinol, 2-chloro-
CAS REGISTRY NUMBER :
6636-78-8
BEILSTEIN REFERENCE NO. :
0002216
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H4-Cl-N-O
MOLECULAR WEIGHT :
129.55
WISWESSER LINE NOTATION :
T6NJ BG CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04685

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S37/39-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UU7707000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Chloro-3-pyridylboronic acid
  • 2-Chloropyridine-3-boronic acid pinacol ester
  • 2-Chloropyridine
  • Pyridin-3-ol
  • 2-Bromo-3-ethoxypyridine
  • 2-Chlorpyridin-3-amin
  • 2-Nitro-3-pyridinol
  • 2-nitro-1-oxy-pyridin-3-ol
  • 3-Pyridinol 1-oxide

DownStream

  • 2-CHLORO-3-BENZYLOXYMETHYLPYRIDINE
  • 2,6-Dichloropyridin-3-ol
  • 2-Chloro-4-nitro-3-pyridinol
  • Furo[2,3-c]pyridin-5-ylmethanol
  • Furo[2,3-c]pyridine-5-carboxylic acid
  • 2-Chloro-6-methoxy-4-[2-(trimethylsilyl)ethynyl]-3-pyridinol
  • 2-Phenylfuro[3,2-b]pyridine
  • 2-Chloro-6-(hydroxymethyl)-3-pyridinol
  • 2-Chloro-6-(hydroxymethyl)-4-iodo-3-pyridinol
  • 5,6-Dimethoxynicotinaldehyde

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Novel heterocyclic systems. Part 21. Synthesis of 3-hydroxypyridine-2 (1H)-selone and its application in the synthesis of 1-azaphenoxaselenine and its substituted derivatives. Smith K, et al.

J. Chem. Soc. Perkin Trans. I , 2075-2079, (1986)

A concise synthesis of all four possible benzo[4,5]furopyridines via palladium-mediated reactions.

Org. Lett. 4(13) , 2201-3, (2002)

[reaction: see text] By taking advantage of the alpha- and gamma-activation of chloropyridines as well as palladium-mediated reactions, all four possible benzo[4,5]furopyridine tricyclic heterocycles,...


More Articles

Related Compounds

  • 2-Chloro-5-hydroxypyridine
  • 2-ethoxyoxan-3-ol
  • 2-iodpyridin-3-ol
  • 2-HEPTNE-3-OL,4,5-DIMETHYL-
  • 2-methyloxolan-3-ol
  • 2-Chloroquinolin-3-ol
  • 1,1,1,2-Tetrafluoro-4-isocyanatobutane
  • KS106 free
  • Benzyl 4-(4-nitrophenoxy)piperidine-1-carboxylate
  • Ethyl 6-formyl-1,4-dimethyl-1,4-dihydropyrrolo[3,2-c]pyrazole-5-carboxylate
  • 2-chloro-4-{1'-[2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-[4,4'-bipiperidin]-1-yl}-N,N-dimethylbenzamide
  • 3-({4-[(7-Methoxy-4-oxo-3,4-dihydroquinazolin-3-yl)methyl]piperidin-1-yl}methyl)benzonitrile
  • (R)-5-[2-(Boc-amino)-3-(5'-chloro-2'-fluoro-4-biphenylyl)propyl]-2,2,5-trimethyl-1,3-dioxane-4,6-dione
  • 1-Bromo-4-fluoro-2-(3-methyl-1-butyn-1-yl)benzene
  • 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenesulfonyl azide
  • 2-(4-Dibenzofuranyl)-4-(2,2-dimethylpropyl)pyridine
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