fenoxaprop-ethyl

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Names

[ Name ]:
fenoxaprop-ethyl

[Synonym ]:
Ethyl 2-{4-[(6-chlorobenzoxazol-2-yl)oxy]phenoxy}propionate
ethyl (RS)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]propionate
ethyl 2-[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]propanoate
EINECS 266-362-9
MFCD00078610
rac-ethyl (2R)-2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}propanoate
ethyl (RS)-2-[4-(6-chlorobenzoxazol-2-yloxy)phenoxy]propionate
Fenoxaprop-ethyl

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
477.5ºC at 760mmHg

[ Melting Point ]:
84-85ºC

[ Molecular Formula ]:
C₁₈H₁₆ClNO₅

[ Molecular Weight ]:
361.77600

[ Flash Point ]:
242.6ºC

[ Exact Mass ]:
361.07200

[ PSA ]:
70.79000

[ LogP ]:
4.60390

[ Index of Refraction ]:
1.587

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA2454000

CHEMICAL NAME :: Propanoic acid, 2-(4-((6-chloro-2-benzoxazolyl)oxy)phenoxy)-, ethyl ester, (+-)-

CAS REGISTRY NUMBER :: 66441-23-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C18-H16-Cl-N-O5

MOLECULAR WEIGHT :: 361.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2357 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,373,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >510 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S17,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,373,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 739 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,625,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4670 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,373,1991

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCWDF Proceedings of the British Crop Protection Conference - Weeds. (British Crop Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1976- Volume(issue)/page/year: -,11,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C136,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 511 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C136,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 605 mg/kg/32D-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S17,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1210 mg/kg/32D-C

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S17,1992

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H410

[ Precautionary Statements ]:
P273-P280-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi,N

[ Risk Phrases ]:
R43;R50/53

[ Safety Phrases ]:
S24;S37;S60;S61

[ RIDADR ]:
UN 3077 9/PG 3

[ RTECS ]:
UA2454000

[ HS Code ]:
2934999023

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenol
Ethyl L-(-)-O-Tosyllactate
2,6-Dichlorobenzoxazole
Ethanol
(R)-2-(4-Hydroxyphenoxy)propanoic acid
L-2-(Benzolsulfonyloxy)propionsaeure-aethylester
l(-)-methanesulfonylethyllactate
Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate

DownStream

4-[(6-Chloro-1,3-benzoxazol-2-yl)oxy]phenol
ethyl 2-{4-[(2-benzoxazolyl)oxy]phenoxy}propanoate
2-Benzoxazolinone
6-Chlorooxazone
6-Hydroxy-2-benzoxazolinone
4-[(6-hydroxy-2-benzoxazolyl)oxy]phenol
ethyl 2-{4-[(6-hydroxy-2-benzoxazolyl)oxy]phenoxy}propanoate
Hydroquinone
Ethyl 2-(4-hydroxyphenoxy)propanoate
Ethyl (R)-(+)-2-(4-hydroxyphenoxy)propionate

Customs

[ HS Code ]: 2934999023

[ Summary ]:
2934999023 2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles

Effect of herbicides on glutathione S-transferases in the earthworm, Eisenia fetida.

Environ. Sci. Pollut. Res. Int. 15(2) , 143-9, (2008)

Earthworms have been studied as a readily available, easily maintainable and cheap test species for assessing chemical pollution, and may be an alternative to in vivo rodent bioassays. The current inv...

Chiral separation of three agrochemical toxins enantiomers by high-performance liquid chromatography on a vancomycin crystalline degradation products-chiral stationary phase.

Biomed. Chromatogr. 21(3) , 234-40, (2007)

This work aims to evaluate for the enantiomeric separations of three agrochemical toxins: haloxyfop-methyl, fenoxaprop-p-ethyl and indoxacarb on crystalline degradation products-chiral stationary phas...

Persistence of herbicide fenoxaprop ethyl and its acid metabolite in soil and wheat crop under Indian tropical conditions.

J. Environ. Sci. Health B 48(5) , 324-30, (2013)

The persistence of fenoxaprop ethyl {Ethyl (RS)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy) phenoxy] propionate} herbicide and its active metabolite fenoxaprop acid was investigated in soil and wheat crop....

fenoxaprop-ethyl
D,L-fenoxaprop-ethyl
(R)-Fenoxaprop-ethyl
ethyl (2R)-2-[4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy]propanoate,ethyl 1-(2,4-dichlorophenyl)-5-(trichloromethyl)-1,2,4-triazole-3-carboxylate
ETHYL (2S)-(+)-2-(4-(6-CHLOROBENZOXAZOL&
9-ethyl-3-[2-(4-imidazol-1-ylphenyl)ethenyl]carbazole
1-(4-(2-(4-aminophenoxy)pyridin-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone
3-methyl-N-(4-(3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yloxy)phenyl)pyridin-2-amine
N-[4-[[3-(2-Methoxyphenyl)-2-pyrazinyl]oxy]phenyl]-2-pyridinamine
2-[4-(2-Pyridinylamino)phenoxy]-N-[2-(2-pyridinyl)ethyl]-3-pyridinecarboxamide
3-(4-(Pyridin-2-ylamino)phenoxy)pyrazine-2-carboxylic acid
1-(4-(2-(4-Aminophenoxy)pyridin-3-yl)piperidin-1-yl)ethanone
N-[2-(1H-Imidazol-5-yl)ethyl]-2-[4-(2-pyridinylamino)phenoxy]-3-pyridinecarboxamide
N-(4-(3-(piperidin-4-yl)pyrazin-2-yloxy)phenyl)pyridin-2-amine
N-[4-(Dimethylamino)butyl]-2-[4-(2-pyridinylamino)phenoxy]-3-pyridinecarboxamide
4-(3-(3,6-dihydro-2H-pyran-4-yl)pyrazin-2-yloxy)aniline

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