ANSAMITOCIN P-4

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Names

[ CAS No. ]:
66547-10-2

[ Name ]:
ANSAMITOCIN P-4

[Synonym ]:
Tam 340
ansamitocin P-4
Maytansinol isovalerate

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
838.7ºC at 760 mmHg

[ Molecular Formula ]:
C33H45ClN2O9

[ Molecular Weight ]:
649.17100

[ Flash Point ]:
461ºC

[ Exact Mass ]:
648.28100

[ PSA ]:
136.16000

[ LogP ]:
5.10750

[ Index of Refraction ]:
1.58

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OQ2295000
CHEMICAL NAME :
Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, isovalerate (ester)
CAS REGISTRY NUMBER :
66547-10-2
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C33-H45-Cl-N2-O9
MOLECULAR WEIGHT :
649.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
625 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
4 ug/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1707,1980

Related Compounds

  • sodium p-[[4-amino-3-(dodecyloxy)-9,10-dihydro-9,10-dioxo-1-anthryl]amino]benzenesulphonate
  • sodium p-[4,5-dihydro-3-methyl-4-[[3-[(p-tolylamino)sulphonyl]-p-tolyl]azo]-5-oxo-1H-pyrazol-1-yl]benzenesulphonate
  • 3-[p-(4-Hydroxyiminobutyryl)phenoxy]-1,2-propanediol
  • Phosphonicacid, P-[(4-chlorophenyl)hydroxymethyl]-, dimethyl ester
  • substance P (4-11), beta-Ala(4)-Sar(9)-Met(02)(11)-
  • Benzenearsonic acid, p-(4-biphenylylsulfamoyl)- (8CI)
  • 3-Amino-2-cyclododecyl-1,1,1-trifluoropropan-2-ol
  • 3-Amino-2-(4-tert-butylcyclohexyl)-1,1,1-trifluoropropan-2-ol
  • 3-Amino-1,1,1-trifluoro-2-(2,2,6,6-tetramethylpiperidin-4-yl)propan-2-ol
  • Tert-butyl 4-(3-amino-1,1,1-trifluoro-2-hydroxypropan-2-yl)piperidine-1-carboxylate
  • 3-Amino-1,1,1-trifluoro-2-(3,3,5,5-tetramethylcyclohexyl)propan-2-ol
  • 4-(3-Amino-1,1,1-trifluoro-2-hydroxypropan-2-yl)-1lambda6-thiane-1,1-dione
  • 2-[1-Ethenyl-4-(2-methylbutan-2-yl)cyclohexyl]acetic acid
  • Tert-butyl 4-amino-2-(2,3-dimethylphenyl)piperidine-1-carboxylate
  • Tert-butyl 4-amino-2-(3,4-dimethylphenyl)piperidine-1-carboxylate
  • Tert-butyl 4-amino-2-(4-bromo-2-fluorophenyl)piperidine-1-carboxylate
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