E-64

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Names

[ CAS No. ]:
66701-25-5

[ Name ]:
E-64

[Synonym ]:
E64
proteinaseinhibitore64
thiolproteaseinhibitor
(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl-agmatin
L-TRANS-EPOXYSUCCINYL-LEU-4-GUANIDINOBUTYLAMIDE
E-64
(2S,3S)-3-({(2S)-1-[(4-Carbamimidamidobutyl)amino]-4-methyl-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylic acid
E-64 PROTEASE INHIBITOR
E-64 HEMIHYDRATE
e64(proteinaseinhibitor)
E-64,L-trans-Epoxysuccinyl-Leu-agMatine
L-TRANS-EPOXYSUCCINYL-LEU-AGMATINE
EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE
2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
MFCD07366493
(2S,3S)-3-({(2S)-1-[(4-Carbamimidamidobutyl)amino]-4-methyl-1-oxo-2-pentanyl}carbamoyl)-2-oxiranecarboxylic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
182ºC

[ Molecular Formula ]:
C15H27N5O5

[ Molecular Weight ]:
357.405

[ Exact Mass ]:
357.201233

[ PSA ]:
169.93000

[ LogP ]:
-1.46

[ Index of Refraction ]:
1.618

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 20 mg/mL, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RR0390000
CHEMICAL NAME :
Oxiranecarboxylic acid, 3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carb onyl)-3-methyl butyl)amino)carbonyl)-, (2S-(2-alpha,3-beta(R*)))-
CAS REGISTRY NUMBER :
66701-25-5
BEILSTEIN REFERENCE NO. :
1405664
LAST UPDATED :
199806
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C15-H27-N5-O5
MOLECULAR WEIGHT :
357.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
60 mg/kg
SEX/DURATION :
female 9-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
APDJBE Acta Paediatrica Japonica (Overseas Edition). (Societas Pediatrica Japonica, 1-1-5-Koraku, Bunkyo-ku, Tokyo, 112, Japan) V.1- 1958- Volume(issue)/page/year: 32,495,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
60 mg/kg
SEX/DURATION :
female 9-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
APDJBE Acta Paediatrica Japonica (Overseas Edition). (Societas Pediatrica Japonica, 1-1-5-Koraku, Bunkyo-ku, Tokyo, 112, Japan) V.1- 1958- Volume(issue)/page/year: 32,495,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
50 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KDIZAA Kagoshima Daigaku Igaku Zasshi. Medical Journal of Kagoshima University. (Kagoshima Daigaku Igakkai, 1208-1, Usuki-cho, Kagoshima 890, Japan) V.1- 1945- Volume(issue)/page/year: 48,1,1996

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H371

[ Precautionary Statements ]:
P260-P264-P270-P308 + P311-P501

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
R68/20/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RR0390000

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Related Compounds

  • E-64 HEMIHYDRATE
  • (E)-1-phenyl-N-pyrimidin-2-ylmethanimine
  • (E)-1-(3-(4-(dimethylamino)butyl)tetrahydropyrimidin-1(2H)-yl)-3-methyldodec-2-en-1-one
  • (E,E)-2-<(4-methoxyphenyl)methylene>-3-(2-thienylmethylene)succinic anhydride
  • (E)-1-(2-Benzoyl-6-hydroxy-3-methyl-benzofuran-5-yl)-3-p-tolyl-propenone
  • (E)-3-bromo-4-oxopent-2-en-2-olate,cobalt(3+)
  • tert-Butyl(3-(ethoxymethyl)-4-iodophenoxy)dimethylsilane
  • 1-(4-Bromo-2-nitrophenyl)-2,2-difluoroethan-1-one
  • Methyl 5-amino-3,3-difluoropentanoate
  • 5-Bromo-3-ethyl-6-fluoro-1H-indole
  • (3R,6R)-4-tert-butoxycarbonyl-6-methyl-morpholine-3-carboxylic acid
  • 4-chloro-3-[(Z)-methoxyiminomethyl]-5-methyl-1H-pyrrole-2-carboxylic acid
  • 2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridine
  • 2-Methylimidazo[1,2-b]pyridazine-7-boronic Acid Pinacol Ester
  • 2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridine
  • 1,2,3,4-Tetrahydro-1-(3-methoxypropyl)-7-quinolinecarboxaldehyde
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