LDN-57444

Suppliers

Names

[ Name ]:
LDN-57444

[Synonym ]:
(3Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)-1,3-dihydro-2H-indol-2-one
3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)-1,3-dihydro-2H-indol-2-one
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime), (3Z)-
LDN-57444

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
534.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₁Cl₃N₂O₃

[ Molecular Weight ]:
397.640

[ Flash Point ]:
277.0±32.9 °C

[ Exact Mass ]:
395.983521

[ PSA ]:
58.97000

[ LogP ]:
4.70

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.655

[ Storage condition ]:
Desiccate at +4°C

[ Water Solubility ]:
DMSO: soluble16mg/mL

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
N

[ Risk Phrases ]:
50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells.

J. Cell. Mol. Med. 18(11) , 2252-65, (2014)

The tumour suppressor activity of the phosphatase and tensin homologue on chromosome 10 (PTEN) is subject of intense investigative efforts, although limited information on its regulation in breast can...

Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair.

Cell Cycle 14(7) , 1103-15, (2015)

Xeroderma pigmentosum group G (XPG) protein is a structure-specific repair endonuclease, which cleaves DNA strands on the 3' side of the DNA damage during nucleotide excision repair (NER). XPG also pl...

NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib.

Oncotarget 6 , 9807-19, (2015)

There is accumulating evidence that TrkA and its ligand Nerve Growth Factor (NGF) are involved in cancer development. Staurosporine derivatives such as K252a and lestaurtinib have been developed to bl...