halobetasol propionate

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Names

[ CAS No. ]:
66852-54-8

[ Name ]:
halobetasol propionate

[Synonym ]:
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate
halobetasolpropionate
halobetasol 17-propionate
(6a,11b,16b)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
21-Chloro-6α,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate
Ultravate
Uiobetasol Propionate
Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6α,11β,16β)-
Miracorten
Halobetasol
ulobetasol propionate
propanoate de (6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(chloroacétyl)-6,9-difluoro-11-hydroxy-10,13,16-triméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yle
(6α,11β,16β)-21-chloro-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(Chloracetyl)-6,9-difluor-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylpropanoat
MFCD00866013
21-Chloro-6a,9-difluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-Propionate
(6α,11β,16β)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate
Halobetasol (propionate)

Chemical & Physical Properties

[ Density]:
0.934 g/mL at 25 °C(lit.)

[ Boiling Point ]:
55 °C0.3 mm Hg(lit.)

[ Melting Point ]:
-32°C

[ Molecular Formula ]:
C25H31ClF2O5

[ Molecular Weight ]:
484.96000

[ Flash Point ]:
185 °F

[ Exact Mass ]:
484.18300

[ PSA ]:
80.67000

[ LogP ]:
4.05110

[ Index of Refraction ]:
n20/D 1.539(lit.)

[ Storage condition ]:
Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3723500
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxo propoxy)-, (6-alpha,11-beta,16-beta)-
CAS REGISTRY NUMBER :
66852-54-8
LAST UPDATED :
199409
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H31-Cl-F2-O5
MOLECULAR WEIGHT :
485.01

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 27,304,1991

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R22:Harmful if swallowed. R23:Toxic by inhalation. R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36-S45-S7/9

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ RTECS ]:
BY4190000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2937229000

Customs

[ HS Code ]: 2937229000

Related Compounds

  • 9-Chloro halobetasol propionate
  • cyclohexylpropyl propionate
  • PROPARGYL PROPIONATE
  • Retinyl Propionate
  • icosanyl propionate
  • Phenylmercuric propionate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Acetamido-2-(1,2-thiazol-5-yl)acetic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • O-[(1-{5H,6H,7H,8H-imidazo[1,2-a]pyridin-2-yl}cyclopropyl)methyl]hydroxylamine
  • 3-[3-(Methoxymethyl)phenyl]morpholine
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde