Dimethyl sulfone

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Names

[ CAS No. ]:
67-71-0

[ Name ]:
Dimethyl sulfone

[Synonym ]:
MFCD00007566
methylsulphonylmethane
Dimethylsulfon
MSM
Methyl sulfone
EINECS 200-665-9
Methylsulfone
METHYLSULPHONE
Sulfone,dimethyl
DIMETHYL SULPHONE
DMSO2
dimethyl sulfone

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
240.9±8.0 °C at 760 mmHg

[ Melting Point ]:
107-109 °C(lit.)

[ Molecular Formula ]:
C2H6O2S

[ Molecular Weight ]:
94.133

[ Flash Point ]:
143.3±0.0 °C

[ Exact Mass ]:
94.008850

[ PSA ]:
42.52000

[ LogP ]:
-1.19

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.402

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
150 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB2785000
CHEMICAL NAME :
Methane, sulfonylbis-
CAS REGISTRY NUMBER :
67-71-0
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C2-H6-O2-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533525
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533525

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
PB2785000

[ HS Code ]:
29309070

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • dms
  • Dimethyl sulfoxide
  • Cyclohexene sulfide
  • 6-amino-1,3-dimethyl-5-[(p-nitrobenzylidene)amino]uracil
  • 3-(4-chlorophenyl)-4-dimethylsulfiliminofurazan
  • 6-amino-5-(benzylideneamino)-1,3-dimethyl-pyrimidine-2,4-dione
  • 6-amino-5-[(4-chlorophenyl)methylideneamino]-1,3-dimethyl-pyrimidine-2,4-dione

DownStream

  • 1-methylsulfonylnonan-2-one
  • Methyl 3,4-dihydroxy-5-methoxybenzoate
  • P-DINITROBENZENE
  • 1-methylsulfinyl-4-nitro-benzene
  • nitrobenzene
  • 4-Nitrobenzonitrile
  • methyl-(2-nitro-phenyl)-sulfoxide
  • 1,2-Dinitrobenzene
  • o-Nitrophenol
  • 5-Methoxyisophthalic acid

Customs

[ HS Code ]: 2904100000

[ Summary ]:
2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Olfactometry Profiles and Quantitation of Volatile Sulfur Compounds of Swiss Tilsit Cheeses.

J. Agric. Food Chem. 63 , 7511-21, (2015)

To establish the odor profiles of three differently fabricated commercial Swiss Tilsit cheeses, analyses were conducted using headspace solid-phase microextraction gas chromatography-mass spectrometry...

The human cerebrospinal fluid metabolome

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 871(2) , 164-73, (2008)

With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive referenc...

Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells.

PLoS ONE 10 , e0141565, (2015)

Metastatic cancer causes 90% of cancer deaths. Unlike many primary tumors, metastatic tumors cannot be cured by surgery alone. Metastatic cancer requires chemotherapy. However, metastatic cells are no...


More Articles

Related Compounds

  • Dimethyl 3-hydroxypentanedioate
  • dimethyl 7,7-dimethoxybicyclo<2.2.1>hept-5-ene-2,3-dicarboxylate
  • dimethyl (2S)-2-tert-butoxycarbonylamino-4-oxohexan-1,6-diotate
  • dimethyl 2H-azirine-2,3-dicarboxylate
  • dimethyl 2-(4-bromobut-2-enyl)-2-prop-1-ynylpropanedioate
  • dimethyl-[3-[2-[[(E)-3-phenylprop-2-enoyl]amino]phenoxy]propyl]azanium,chloride
  • 7-(1-Amino-3-methylbutyl)naphthalen-2-ol
  • (3R)-3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynamido]pentanoic acid
  • 3-{[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]methyl}-4-methylpentanoic acid
  • Benzyl 4-(4-hydroxyoxan-4-yl)piperidine-1-carboxylate
  • 3-[2-(cyclopropylmethyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-3-methylbutanoic acid
  • (3R,4R)-4-(3-bromophenoxy)oxolan-3-ol
  • 4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexanecarbonyl]thiomorpholine-2-carboxylic acid
  • 2-{1-[8-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)octanamido]cyclopropyl}acetic acid
  • 5-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]pyridine-2-carboxylic acid
  • 3-[benzyl(methyl)amino]-2-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylhexanamido]propanoic acid
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