6-O-Acetyl Codeine

Names

[ CAS No. ]:
6703-27-1

[ Name ]:
6-O-Acetyl Codeine

[Synonym ]:
[(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] acetate

Chemical & Physical Properties

[ Density]:
1.3 g/cm3

[ Boiling Point ]:
461.2ºC at 760 mmHg

[ Melting Point ]:
132-134ºC

[ Molecular Formula ]:
C20H23NO4

[ Molecular Weight ]:
341.40100

[ Flash Point ]:
232.7ºC

[ Exact Mass ]:
341.16300

[ PSA ]:
48.00000

[ LogP ]:
2.00980

[ Index of Refraction ]:
1.627

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD0960000
CHEMICAL NAME :
Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, acetate
CAS REGISTRY NUMBER :
6703-27-1
LAST UPDATED :
199106
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H23-N-O4
MOLECULAR WEIGHT :
341.44
WISWESSER LINE NOTATION :
T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FOV1 JO1 P1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
99 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZNAE "Public Health Reports, Supplement." (Washington, DC) Volume(issue)/page/year: 138,10,1938

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ RIDADR ]:
UN 1648 3 / PGII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanoic anhydride
  • Codeinone
  • Codeine Phosphate
  • (-)-codeine

DownStream

  • 14-Hydroxy Codeinone

Articles

Development and validation of a solid-phase extraction gas chromatography-mass spectrometry method for the simultaneous quantification of methadone, heroin, cocaine and metabolites in sweat.

Anal. Bioanal. Chem 392(1-2) , 115-27, (2008)

A sensitive and specific method is presented to simultaneously quantify methadone, heroin, cocaine and metabolites in sweat. Drugs were eluted from sweat patches with sodium acetate buffer, followed b...

The detection of acetylcodeine and 6-acetylmorphine in opiate positive urines.

Forensic Sci. Int. 95(1) , 1-10, (1998)

Acetylcodeine (AC), an impurity of illicit heroin synthesis, was investigated as a urinary biomarker for detection of illicit heroin use. One hundred criminal justice urine specimens that had been con...

Detection of non-prescription heroin markers in urine with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.

J. Anal. Toxicol. 25(6) , 431-8, (2001)

The planned introduction of a prescription heroin program in Germany created a need for differentiation between non-prescription and prescribed diamorphine use. The following substances were chosen as...


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