Eflornithine

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Names

[ CAS No. ]:
67037-37-0

[ Name ]:
Eflornithine

[Synonym ]:
Eflornithine

Chemical & Physical Properties

[ Density]:
1.293g/cm3

[ Boiling Point ]:
347ºC at 760 mmHg

[ Molecular Formula ]:
C6H12F2N2O2

[ Molecular Weight ]:
182.16800

[ Flash Point ]:
163.7ºC

[ Exact Mass ]:
182.08700

[ PSA ]:
89.34000

[ LogP ]:
1.17310

[ Index of Refraction ]:
1.462

[ Storage condition ]:
-15°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RM2981700
CHEMICAL NAME :
DL-Ornithine, 2-(difluoromethyl)-
CAS REGISTRY NUMBER :
67037-37-0
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C6-H12-F2-N2-O2
MOLECULAR WEIGHT :
182.20
WISWESSER LINE NOTATION :
Z3XZVQYFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1364 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
291 mg/kg/52W-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Liver - changes in liver weight Blood - changes in platelet count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 gm/kg
SEX/DURATION :
female 5-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3952 mg/kg
SEX/DURATION :
female 5-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
24750 mg/kg
SEX/DURATION :
female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
300 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Kidney
DOSE/DURATION :
500 umol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 108,85,1988

Related Compounds

  • Eflornithine
  • L-Eflornithine
  • EflornithineHcl
  • Eflornithine API
  • Eflornithine Hydrocloride
  • L-Eflornithine monohydrochloride
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