4-Hydroxy-5-fluorpyrimidine

Suppliers

Names

[ CAS No. ]:
671-35-2

[ Name ]:
4-Hydroxy-5-fluorpyrimidine

[Synonym ]:
5-fluoro-1H-pyrimidin-6-one
MFCD00223674

Chemical & Physical Properties

[ Density]:
1.46 g/cm3

[ Boiling Point ]:
200.5ºC at 760 mmHg

[ Molecular Formula ]:
C4H3FN2O

[ Molecular Weight ]:
114.07800

[ Flash Point ]:
81.6ºC

[ Exact Mass ]:
114.02300

[ PSA ]:
46.01000

[ LogP ]:
0.32130

[ Index of Refraction ]:
1.369

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW7450000
CHEMICAL NAME :
4(1H)-Pyrimidinone, 5-fluoro-
CAS REGISTRY NUMBER :
671-35-2
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H3-F-N2-O
MOLECULAR WEIGHT :
114.09
WISWESSER LINE NOTATION :
T6N CNJ DQ EF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Tumorigenic - active as anti-cancer agent
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
72 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Tumorigenic - active as anti-cancer agent
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 28,159,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1435 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Tumorigenic - active as anti-cancer agent
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
175 mg/kg/7D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ HS Code ]:
2933599090

Precursor & DownStream

Precursor

DownStream

  • 4-Chloro-5-fluoropyrimidine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-Hydroxy-5,6,7,8-tetrahydroquinolin-2(1H)-one
  • 4-Hydroxy-5,6-undecadiene-8,10-diynoic acid
  • 4-Hydroxy-5-isopropyl-2-methylbenzoic acid
  • 4-hydroxy-5,7-dimethylchromen-2-one
  • 4-hydroxy-5,6,7,8-tetrahydronaphthalene-1-sulfonic acid
  • 4-hydroxy-5-nitro-6-oxo-1H-pyridine-3-carboxamide
  • 2-Chloro-6-(difluoromethyl)pyridine-3-methanol
  • 2-(2-Chloro-3-cyano-5-(difluoromethyl)pyridin-4-yl)acetic acid
  • 3-Amino-1-(3-ethoxyphenyl)propan-1-one
  • 1-[4-(Methylamino)oxolan-3-yl]prop-2-en-1-one
  • 1-(Bromomethyl)-4-(difluoromethyl)naphthalene
  • 2,2-difluoro-1-(1-methyl-1H-1,2,3-triazol-5-yl)ethan-1-one
  • 2-[(4-Bromo-2-pyridinyl)methyl]-1H-isoindole-1,3(2H)-dione
  • 2-(2,6-Dichlorophenyl)-4-methyl-3-nitropyridine
  • 2-(2,3-Difluorophenyl)-5-methylthiophene
  • 1-(Cyclopentylmethoxy)-1-(iodomethyl)-4-methylcyclohexane
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