5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

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Names

[ CAS No. ]:
67219-55-0

[ Name ]:
5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

[Synonym ]:
N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
EINECS 266-605-9
MFCD00010114
5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

Chemical & Physical Properties

[ Density]:
1.27 g/cm3

[ Melting Point ]:
119 °C

[ Molecular Formula ]:
C37H35N3O7

[ Molecular Weight ]:
633.69000

[ Exact Mass ]:
633.24800

[ PSA ]:
121.14000

[ LogP ]:
5.24290

[ Index of Refraction ]:
58 ° (C=1, MeOH)

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H340-H350

[ Precautionary Statements ]:
P201-P280-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4,4'-Dimethoxytrityl chloride
  • N4-Benzoyl-2'-deoxycytidine
  • 2'-Deoxycytidine monohydrate
  • 5'-O-(4,4'-dimethoxytrityl)-4-N-benzoyl-2'-deoxycytidine-3'-H-phosphonate triethylammonium salt
  • Benzoyl chloride
  • 2'-Deoxycytidine hydrochloride
  • benzoic acid
  • N,3'-O,5'-O-Tribenzoyl-2'-deoxycytidine

DownStream

  • N4-Benzoyl-2'-deoxycytidine
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-2'-DEOXYCYTIDINE-3'-O-SUCCINIC ACID
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE
  • N4-(3-aminopropyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
  • 2'-DEOXYCYTIDINE-3'-MONOPHOSPHATE

Articles

Diels-Alder cycloadditions in water for the straightforward preparation of peptide-oligonucleotide conjugates.

Nucleic Acids Res. 34(3) , e24, (2006)

The Diels-Alder reaction between diene-modified oligonucleotides and maleimide-derivatized peptides afforded peptide-oligonucleotide conjugates with high purity and yield. Synthesis of the reagents wa...

Aldrichimica Acta 20 , 52, (1987)


More Articles

Related Compounds

  • 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N4-benzoylcytidine
  • 5'-O-(Dimethoxytrityl)-N-isobutyryl-2'-deoxycytidine
  • 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate
  • 5'-o-(dimethoxytrityl)-n-(dimethylamino)methylidene-2'-deoxypseudoisocytidine
  • 5'-O-(4,4'-dimethoxytrityl)N-benzoyl-cytosine-3'-O-(2-cyanoethyl) H-phosphonate
  • N4-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYCYTIDINE
  • 3-(propane-2-sulfonyl)-N-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzamide
  • N-(4-(5-chlorothiophen-2-yl)thiazol-2-yl)-3-(isopropylsulfonyl)benzamide
  • N-(4-(5-bromothiophen-2-yl)thiazol-2-yl)-3-(isopropylsulfonyl)benzamide
  • N-(4-(benzo[d][1,3]dioxol-5-yl)thiazol-2-yl)-3-(isopropylsulfonyl)benzamide
  • N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)-3-(isopropylsulfonyl)benzamide
  • N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-3-(isopropylsulfonyl)benzamide
  • N-(4-(benzo[d]thiazol-2-yl)thiazol-2-yl)-3-(isopropylsulfonyl)benzamide
  • 3-(3-(Isopropylsulfonyl)benzamido)benzofuran-2-carboxamide
  • N-(4H-chromeno[4,3-d]thiazol-2-yl)-3-(isopropylsulfonyl)benzamide
  • 3-(isopropylsulfonyl)-N-(4-nitrophenyl)benzamide
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