1-Nitrosoguanidine

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Names

[ CAS No. ]:
674-81-7

[ Name ]:
1-Nitrosoguanidine

[Synonym ]:
1-Nitrosoguanidine
Nitrosoguanidine
Nitrosoguanidines
Nitrosoguanidin
MFCD00059593
N-Nitrosoguanidine
GUANIDINE,NITROSO
Guanidine, N-nitroso-

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
131.6±23.0 °C at 760 mmHg

[ Molecular Formula ]:
CH4N4O

[ Molecular Weight ]:
88.069

[ Flash Point ]:
33.4±22.6 °C

[ Exact Mass ]:
88.038513

[ PSA ]:
91.33000

[ LogP ]:
-1.25

[ Vapour Pressure ]:
9.2±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.665

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF4725000
CHEMICAL NAME :
Guanidine, nitroso-
CAS REGISTRY NUMBER :
674-81-7
LAST UPDATED :
199406
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C-H4-N4-O
MOLECULAR WEIGHT :
88.09
WISWESSER LINE NOTATION :
ONMYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,563,1993
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,563,1993
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 23,288,1972
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,563,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83966 No. of Facilities: 61 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 442 (estimated)

Safety Information

[ Risk Phrases ]:
11-20/21/22-36/37/38

[ Safety Phrases ]:
S16;S26;S36/S37/S39

[ RIDADR ]:
UN 1325

Synthetic Route

Precursor & DownStream

Precursor

  • Nitroguanidine
  • Carbonic acid-guanidine (1:2)
  • Sodium nitrite
  • Sulfuric acid

DownStream

  • Nitroguanidine
  • Cyanamide
  • Carbon dioxide
  • Ammonia
  • Hydrazinecarboximidamide(9CI)
  • 2-(diaminomethylideneamino)guanidine
  • melamine
  • Cyanuramide
  • guanidine
  • Cyanurodiamide

Related Compounds

  • 2-ethyl-1-nitrosoguanidine
  • 1-ethyl-1-nitrosoguanidine
  • 1-nitro-1-nitrosoguanidine
  • 2-methyl-1-nitrosoguanidine
  • 1-Amyl-3-nitro-1-nitrosoguanidine
  • 2-ethyl-1-nitro-1-nitrosoguanidine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4-(5,6-Dichloro-3-ethyl-2-{3-[1-(3-sulfopropyl)naphtho[1,2-d][1,3]thiazol-2(1H)-ylidene]prop-1-en-1-yl}-1H-benzimidazol-3-ium-1-yl)butane-2-sulfonate--N,N-diethylethanamine (1/1)
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide