2-Chloro-N-methoxy-N-methylacetamide

Names

[ CAS No. ]:
67442-07-3

[ Name ]:
2-Chloro-N-methoxy-N-methylacetamide

[Synonym ]:
2-Chloro-N-methoxy-N-methylacetamide
Acetamide, 2-chloro-N-methoxy-N-methyl-
MFCD00134232
G1VN1&O1

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
141.5±42.0 °C at 760 mmHg

[ Melting Point ]:
39-41 °C(lit.)

[ Molecular Formula ]:
C₄H₈ClNO₂

[ Molecular Weight ]:
137.565

[ Flash Point ]:
104.4±0.0 °C

[ Exact Mass ]:
137.024353

[ PSA ]:
29.54000

[ LogP ]:
-0.08

[ Vapour Pressure ]:
5.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.443

[ Storage condition ]:
Refrigerator

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S23-S26-S27-S28-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2-Chloro-1-(5-fluoro-2-pyridyl)ethanone
Diphenyl (N-Methoxy-N-methylcarbamoylmethyl)phosphonate
1-Chloro-3-phenylacetone
2-chloro-1-[6-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl]ethanone
N-methoxy-2-[(4-methoxyphenyl)methoxy]-N-methylacetamide
1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE
N-Methoxy-N-methylacetamide
n-methoxy-n-methyl(triphenyl-phosphoranylidene)acetamide
diethyl (n-methoxy-n-methylcarbamoylmethyl)phosphonate
1-(5-Bromo-2-pyridinyl)-2-chloroethanone

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues.

Org. Biomol. Chem. 9(1) , 57-61, (2011)

Expedient syntheses of Pseudomonas quinolone signal (PQS) and related structural analogues using microwave and flow methods are reported.

Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs.

Nat. Protoc. 7(6) , 1184-92, (2012)

An optimized procedure for the efficient preparation of 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and a diverse range of structurally related 2-alkyl-4-quinolones with b...

New Reagent for Convenient Access to the a, ß-Unsaturated N-Methoxy-N-methyl-amide Functionality by a Synthesis Based on the Julia Olefination Protocol. Narayana Manjunath B, et al

European J. Org. Chem. 12 , 2851-55, (2006)

2-CHLORO N-METHOXY N METHYL ACETAMIDE
2-chloro-N-methoxy-N-methyl-2-phenylethanamine,hydrochloride
2-chloro-N-methoxy-N-methyl-4-nitrobenzamide
4-bromo-2-chloro-N-methoxy-N-methyl-benzamide
2-Cyclopropyl-N-methoxy-N-methyl-acetamide
2-BROMO-N-METHOXY-N-METHYL ACETAMIDE