GBR 12935 dihydrochloride

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Names

[ Name ]:
GBR 12935 dihydrochloride

[Synonym ]:
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2)
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
GBR 12935 dihydrochloride
GBR 12935 (dihydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
564ºC at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₆Cl₂N₂O

[ Molecular Weight ]:
487.504

[ Flash Point ]:
294.9ºC

[ Exact Mass ]:
486.220459

[ PSA ]:
15.71000

[ LogP ]:
6.52280

[ Appearance of Characters ]:
white solid

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

Plasma membrane monoamine transporters: structure, regulation and function.

Nat. Rev. Neurosci. 4 , 13-25, (2003)

Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.

J. Pharmacol. Exp. Ther. 268 , 1462-1475, (1994)

The present study addressed the hypothesis that there exist multiple sites/states associated with the dopamine (DA) transporter ligands. The authors used [3H](1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylp...

[3H]GBR-12935 binding to cytochrome P450 in the human brain.

J. Neurochem. 62 , 342-348, (1994)

The presence of multiple [3H]GBR-12935 binding sites in the human brain has been revealed in several recent studies. One site represents the dopamine uptake site. In rat brain it was demonstrated that...

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