Methylphosphonic dichloride

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Names

[ CAS No. ]:
676-97-1

[ Name ]:
Methylphosphonic dichloride

[Synonym ]:
EINECS 211-634-4
Methanephosphonyl chloride
MFCD00002071
Methylphosphonyl dichloride
Methylphosphonicdichlorid
Phosphonic dichloride, P-methyl-
dichlorophosphorylmethane
Methyl phosphonyl dichloride

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
163.0±0.0 °C at 760 mmHg

[ Melting Point ]:
32-60ºC

[ Molecular Formula ]:
CH₃Cl₂OP

[ Molecular Weight ]:
132.914

[ Flash Point ]:
44.1±18.7 °C

[ Exact Mass ]:
131.929855

[ PSA ]:
26.88000

[ LogP ]:
0.25

[ Vapour Pressure ]:
2.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.420

[ Stability ]:
Stable, but may decompose in the presence of water or moisture. Incompatible with water, strong bases, strong oxidizing agents.

[ Water Solubility ]:
Soluble in water.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TA1840000

CHEMICAL NAME :: Phosphonic dichloride, methyl-

CAS REGISTRY NUMBER :: 676-97-1

BEILSTEIN REFERENCE NO. :: 1071305

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C-H3-Cl2-O-P

MOLECULAR WEIGHT :: 132.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 ppm/4H

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,470,1964

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H330

[ Supplemental HS ]:
Contact with water liberates toxic gas., Reacts violently with water.

[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
R14;R26;R34

[ Safety Phrases ]:
S26-S28-S36/37/39-S45

[ RIDADR ]:
UN 3390 6

[ WGK Germany ]:
3

[ RTECS ]:
TA1840000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1

Precursor & DownStream

Precursor

DownStream

1-[chloro(methyl)phosphoryl]oxyoctane
2,6-dimethyl-1,3,6,2λ5-dioxazaphosphocane 2-oxide
1-chloro-4-[(4-chlorophenoxy)-methylphosphoryl]oxybenzene
Phosphonic acid,P-methyl-, bis(4-nitrophenyl) ester
1-[chloro(methyl)phosphoryl]oxy-4-nitrobenzene
Hydrochloric acid
hydroxy-methyl-oxophosphanium

Articles

Kinetics and mechanism of beta-lactamase inhibition by phosphonamidates: the quest for a proton.

Biochemistry 32 , 10763, (1993)

Four phosphonamidates were synthesized as potential beta-lactamase inhibitors. Three were methanephosphonamidates [CH3PO2-NHR/Ar, where R/Ar = 4-methoxybenzyl (3a), phenyl (3b), and m-nitrophenyl (3c)...

Helv. Chim. Acta 75 , 2520, (1992)

Synth. Commun. 23 , 2273, (1993)

Methylphosphonic acid dipropyl ester
Methylphosphonic acid cyclohexyl 2-(dipropylamino)ethyl ester
Methylphosphonic acid
Methylphosphonic acid 4-nitrophenyl 2-(4-nitrophenyl)-2-oxoethyl ester
methylphosphonic acid phenyl ester propyl ester
methylphosphonic acid,pyridine
(1R,2S)-2-fluorocyclopropanesulfonyl chloride
N-Hydroxy-N-methylcyclobutanecarboxamide
(R)-3-Phenoxytetrahydrofuran
3-(Azetidin-3-yl)azetidine
6,7-Dihydro-N4-[(2-methylphenyl)methyl]-N2-(2-pyridinylmethyl)-5H-cyclopentapyrimidine-2,4-diamine
4-Bromo-1-iodo-2-(methoxymethoxy)benzene
5-Bromo-3-[(5,6,7,8-tetrahydro-5-quinolinyl)oxy]-2-pyridinamine
8-Ethyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride
Methyl 2,3-dichloroquinoline-6-carboxylate
Tert-butyl 2-(sulfanylmethyl)morpholine-4-carboxylate

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