Methylphosphonic dichloride

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Names

[ CAS No. ]:
676-97-1

[ Name ]:
Methylphosphonic dichloride

[Synonym ]:
EINECS 211-634-4
Methanephosphonyl chloride
MFCD00002071
Methylphosphonyl dichloride
Methylphosphonicdichlorid
Phosphonic dichloride, P-methyl-
dichlorophosphorylmethane
Methyl phosphonyl dichloride

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
163.0±0.0 °C at 760 mmHg

[ Melting Point ]:
32-60ºC

[ Molecular Formula ]:
CH3Cl2OP

[ Molecular Weight ]:
132.914

[ Flash Point ]:
44.1±18.7 °C

[ Exact Mass ]:
131.929855

[ PSA ]:
26.88000

[ LogP ]:
0.25

[ Vapour Pressure ]:
2.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.420

[ Stability ]:
Stable, but may decompose in the presence of water or moisture. Incompatible with water, strong bases, strong oxidizing agents.

[ Water Solubility ]:
Soluble in water.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TA1840000
CHEMICAL NAME :
Phosphonic dichloride, methyl-
CAS REGISTRY NUMBER :
676-97-1
BEILSTEIN REFERENCE NO. :
1071305
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C-H3-Cl2-O-P
MOLECULAR WEIGHT :
132.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26 ppm/4H
TOXIC EFFECTS :
Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,470,1964

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H330

[ Supplemental HS ]:
Contact with water liberates toxic gas., Reacts violently with water.

[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
R14;R26;R34

[ Safety Phrases ]:
S26-S28-S36/37/39-S45

[ RIDADR ]:
UN 3390 6

[ WGK Germany ]:
3

[ RTECS ]:
TA1840000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1

Precursor & DownStream

Precursor

DownStream

  • 1-[chloro(methyl)phosphoryl]oxyoctane
  • 2,6-dimethyl-1,3,6,2λ5-dioxazaphosphocane 2-oxide
  • 1-chloro-4-[(4-chlorophenoxy)-methylphosphoryl]oxybenzene
  • Phosphonic acid,P-methyl-, bis(4-nitrophenyl) ester
  • 1-[chloro(methyl)phosphoryl]oxy-4-nitrobenzene
  • Hydrochloric acid
  • hydroxy-methyl-oxophosphanium

Articles

Kinetics and mechanism of beta-lactamase inhibition by phosphonamidates: the quest for a proton.

Biochemistry 32 , 10763, (1993)

Four phosphonamidates were synthesized as potential beta-lactamase inhibitors. Three were methanephosphonamidates [CH3PO2-NHR/Ar, where R/Ar = 4-methoxybenzyl (3a), phenyl (3b), and m-nitrophenyl (3c)...

Helv. Chim. Acta 75 , 2520, (1992)

Synth. Commun. 23 , 2273, (1993)


More Articles

Related Compounds

  • Methylphosphonic acid dipropyl ester
  • Methylphosphonic acid cyclohexyl 2-(dipropylamino)ethyl ester
  • Methylphosphonic acid
  • Methylphosphonic acid 4-nitrophenyl 2-(4-nitrophenyl)-2-oxoethyl ester
  • methylphosphonic acid phenyl ester propyl ester
  • methylphosphonic acid,pyridine
  • (Z)-2-Cyano-3-phenyl-N-[2-(4-propan-2-yl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)ethyl]prop-2-enamide
  • 2-Bromo-4-chloronaphthalen-1-amine
  • (E)-2-Cyano-3-[2,5-dimethyl-1-(2-methylpropyl)pyrrol-3-yl]-N-(1-pyridin-2-ylethyl)prop-2-enamide
  • Ethyl 2-(3-(4-bromophenyl)oxetan-3-YL)acetate
  • (Z)-2-Cyano-3-(furan-2-yl)-N-[3-(4-methyl-6-oxo-1H-pyrimidin-2-yl)phenyl]prop-2-enamide
  • 3,3-Dimethyl-4-[1-(quinoline-3-carbonyl)piperidin-4-yl]azetidin-2-one
  • tert-Butyl ((1r,4r)-4-(5-bromothiazol-2-yl)cyclohexyl)carbamate
  • 2-bromo-N-(tert-butyl)-5-nitrobenzenesulfonamide
  • Rel-tert-butyl ((1r,4r)-4-carbamothioylcyclohexyl)carbamate
  • 2-(2-bromothiazol-5-yl)-N-(tert-butyl)-5-nitrobenzenesulfonamide
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