N-acetyl-L-proline

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Names

[ CAS No. ]:
68-95-1

[ Name ]:
N-acetyl-L-proline

[Synonym ]:
N-Acetyl-L-proline
EINECS 200-698-9
Proline, 1-acetyl-, L-
MFCD00020837
(2S)-1-acetylpyrrolidine-2-carboxylic acid
L-Proline, 1-acetyl-
1-Acetyl-L-proline
N-Acethyl-L-proline
Ac-Pro-OH

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
366.2±35.0 °C at 760 mmHg

[ Melting Point ]:
115-117 °C

[ Molecular Formula ]:
C7H11NO3

[ Molecular Weight ]:
157.17

[ Flash Point ]:
175.3±25.9 °C

[ Exact Mass ]:
157.073898

[ PSA ]:
57.61000

[ LogP ]:
-0.77

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.517

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ Packaging Group ]:
I; II; III

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetyl chloride
  • Proline
  • Ethanoic anhydride
  • N-Ac-Pro-OMe
  • (S)-Pyrrolidine-2-carboxylic acid ethyl ester hydrochloride
  • acetic acid
  • H-DL-PRO-NH2
  • ketene
  • vinyl acetate
  • N-(N'-acetyl-L-prolyl)-N-nitroso-L-alanine

DownStream

  • Proline
  • 1-Acetyl-L-prolinamide
  • 2-acetamido-3-(5-methoxy-1H-indol-3-yl)propanoic acid
  • 1-(2-methoxypyrrolidin-1-yl)ethanone

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Quantum mechanical and NMR studies of ring puckering and cis/trans-rotameric interconversion in prolines and hydroxyprolines.

J. Phys. Chem. A 113(40) , 10858-65, (2009)

Nuclear magnetic resonance (NMR) and quantum mechanical (QM) studies have been carried out for proline (Pro) containing peptides: N-acetyl-l-proline (AcProOH) and N-acetyl-4-hydroxy-l-proline (AcHypOH...

Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.

J. Med. Chem. 31 , 1148-1160, (1988)

Analogues of captopril, enalaprilat, and the phosphinic acid [hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline incorporating 4-substituted proline derivatives have been synthesized and evaluated as ...

Synergistic binding of ligands to angiotensin-converting enzyme.

J. Biol. Chem. 263 , 4056-4068, (1988)

We have investigated the interaction of ligands in the active site of the angiotensin-converting enzyme from rabbit lung by monitoring the concurrent effects of two inhibitors on enzyme activity. A st...


More Articles

Related Compounds

  • N-acetyl-L-proline amide
  • N-acetyl-L-proline benzyl ester
  • N-acetyl-L-proline methyl ester
  • N-Acetyl-L-proline (N-Ac-L-Pro)
  • N-acetyl-L-proline methyl ester
  • N-acetyl-L-proline-N'-methylamide
  • 3-(2-Bromo-3-fluorophenyl)butan-1-amine
  • 1-(3,5-Dichloro-2-methoxyphenyl)cyclobutan-1-amine
  • 3-[2-Fluoro-4-(trifluoromethyl)phenyl]-1,2-oxazol-5-amine
  • 2-(2,4-Difluoro-3,5-dimethoxyphenyl)-2-oxoacetic acid
  • 2-(Bromomethyl)-6-(difluoromethyl)pyridine-4-carboxaldehyde
  • 2-(Chloromethyl)-3-(difluoromethyl)pyridine-6-acetic acid
  • 2-(Chloromethyl)-3-cyano-4-(difluoromethyl)pyridine-6-acetic acid
  • 2-(Chloromethyl)-3-(difluoromethyl)-5-fluoro-4-nitropyridine
  • 2-(Chloromethyl)-5-(3-(trifluoromethyl)phenyl)pyrimidine
  • 2-(Chloromethyl)-3-(difluoromethyl)-6-methylpyridine-4-acetonitrile
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