2-AMINO-3-METHYL-9H-PYRIDO[2,3-B]INDOLE

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Names

[ CAS No. ]:
68006-83-7

[ Name ]:
2-AMINO-3-METHYL-9H-PYRIDO[2,3-B]INDOLE

[Synonym ]:
Glob-P-1

Chemical & Physical Properties

[ Density]:
1.334g/cm3

[ Boiling Point ]:
443.2ºC at 760mmHg

[ Melting Point ]:
215-218ºC

[ Molecular Formula ]:
C12H11N3

[ Molecular Weight ]:
197.23600

[ Flash Point ]:
252.1ºC

[ Exact Mass ]:
197.09500

[ PSA ]:
54.70000

[ LogP ]:
3.18790

[ Index of Refraction ]:
1.806

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU9354380
CHEMICAL NAME :
9H-Pyrido(2,3-b)indole, 2-amino-3-methyl-
CAS REGISTRY NUMBER :
68006-83-7
LAST UPDATED :
199712
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C12-H11-N3
MOLECULAR WEIGHT :
197.26
WISWESSER LINE NOTATION :
T B656 FN HMJ D1 EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
420 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32800 mg/kg/85W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
37380 mg/kg/64W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35424 mg/kg/70W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
DNA adduct

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
125 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 269,79,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,253,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,253,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-benzylamino-9-benzyl-3-methylpyrido[2,3-b]indole
  • 1-Benzyl-2-azido-1H-indole-3-carbaldehyde
  • 1H-Indol-2-amine hydrochloride (1:1)
  • 3-amino-2-methylacrylonitrile

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-AMino-3-Methyl-9H-pyrido[2,3-b]indole-d3
  • N-(3-methyl-9H-pyrido[2,3-b]indol-2-yl)hydroxylamine
  • acetic acid,3-methyl-9H-pyrido[2,3-b]indol-2-amine
  • 2-Amino-3-propyl-9H-pyrido(2,3-b)indole
  • 2-Amino-3-ethyl-9H-pyrido(2,3-b)indole
  • 2-Nitro-3-methyl-9H-pyrido[2,3-b]indole
  • N-(2-(3-(4-methoxyphenyl)-6-oxopyridazin-1(6H)-yl)ethyl)-3-methylbenzamide
  • ethyl-(2S)-4-methylene-N-(t-butoxycarbonyl)pyroglutamate
  • N-(2-(6-oxo-3-phenylpyridazin-1(6H)-yl)ethyl)-3-(trifluoromethyl)benzenesulfonamide
  • N-(2-(3-(4-fluorophenyl)-6-oxopyridazin-1(6H)-yl)ethyl)-4-(trifluoromethyl)benzenesulfonamide
  • 7-Methoxybenzo[d]isoxazole
  • N-(benzo[d][1,3]dioxol-5-yl)-2-((7-phenyl-6,7-dihydro-5H-imidazo[2,1-c][1,2,4]triazol-3-yl)thio)acetamide
  • N-(4-fluorobenzyl)-2-((7-(4-methoxyphenyl)-6,7-dihydro-5H-imidazo[2,1-c][1,2,4]triazol-3-yl)thio)acetamide
  • 2-(4-fluorophenoxy)-N-(3-methyl-1-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1H-pyrazol-5-yl)acetamide
  • Hept-6-yn-1-amine
  • Methyl 3-hydroxycyclohex-1-ene-1-carboxylate
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