Diethyl isopropylidenemalonate

Suppliers

Names

[ Name ]:
Diethyl isopropylidenemalonate

[Synonym ]:
Diethyl isopropylidenemalonate
diethyl 2-propan-2-ylidenepropanedioate
EINECS 229-876-4
Propanedioic acid, (1-methylethylidene)-, diethyl ester
Malonic acid, isopropylidene-, diethyl ester
Propanedioic acid, 2-(1-methylethylidene)-, diethyl ester
MFCD00009147

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
242.8±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆O₄

[ Molecular Weight ]:
200.232

[ Flash Point ]:
109.4±0.0 °C

[ Exact Mass ]:
200.104858

[ PSA ]:
52.60000

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.446

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2917190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Diethyl malonate
diethyl 2-(1-bromopropan-2-ylidene)propanedioate
Acetone
Propane,2-chloro-2-nitro-
sodium 1,3-diethoxy-1,3-dioxopropan-2-ide
(2-methoxycarbonyl-prop-2-yl) triphenylphosphonium iodide
Diethyl ketomalonate
Diethyl ethoxymethylenemalonate

DownStream

DIETHYL 2-METHYLENECYCLOPROPANE-1,1-DICARBOXYLATE
3,3-dimethylpentanoic acid
Butyroin
Cyclobutanol
dimethyl-1,1 oxo-2 pentyl malonate d'ethyle
β-methoxyaminoisopropylmalonic acid diethyl ester
Diethyl malonate
2,2-dimethylbutylbenzene
Heptanetetracarboxylicacid, 4-(1-methylethylidene)-, 1,2,6,7-tetraethyl ester
Heptanedioic acid,4-(1-methylethylidene)-

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Terminal bifunctional retinoids. Synthesis and evaluations related to cancer chemopreventive activity.

J. Med. Chem. 31(6) , 1124-30, (1988)

Retinoids that have two functional groups at the side-chain terminus have been synthesized. The two terminal functional groups are combinations of the carboxyl, carbethoxy, and N-(ethylamino)carbonyl ...

Reduction of alkylidenecyanoacetates with sodium borohydride. Marshall JA and Carroll RD.

J. Org. Chem. 30(8) , 2748-54, (1965)

diethyl 2-hydroxy-3-(1,2,4-triazol-1-yl)propylphosphonate
diethyl (4-methoxyphenylthio)methylphosphonate
diethyl N-methylaminomethylphosphonate
diethyl 1-cyano-1-(4-isobutylphenyl)ethylphosphate
diethyl 2-(1-ethylsulfanyl-2-methylpropyl)propanedioate
diethyl 2-benzyl-2-pentylpropanedioate
(Z)-2-(4-(tert-butyl)benzylidene)-7-((dimethylamino)methyl)-6-hydroxybenzofuran-3(2H)-one
2-[(1-Ethylindol-3-yl)methylene]-7-methyl-3-oxobenzo[3,4-b]furan-6-yl acetate
(2R)-3-(3-chloro-4-methoxyphenyl)-2-[[(E)-4-[(2S,3R,4R,5S)-4-hydroxy-3-methyl-5-phenyloxolan-2-yl]but-2-enoyl]amino]propanoic acid
4-(1H-indol-3-yl)-N-[4-(trifluoromethoxy)phenyl]butanamide
6-({[1-(4-fluorophenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}amino)hexanoic acid
6-(5-Bromo-3-pyridinyl)-3-(3-chlorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
2-(4-methoxyphenyl)-N-(5-(propylsulfonyl)-1,3,4-thiadiazol-2-yl)acetamide
Ethyl 2-[(4-chlorobenzyl)sulfanyl]-5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate
(2Z)-2-[(6-bromo-4H-1,3-benzodioxin-8-yl)methylidene]-6-[(4-methoxybenzyl)oxy]-1-benzofuran-3(2H)-one
1-[(2-chlorophenyl)methyl]-N-(4-acetamidophenyl)-6-oxo-1,6-dihydropyridine-3-carboxamide

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