Sorbinil

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Names

[ CAS No. ]:
68367-52-2

[ Name ]:
Sorbinil

[Synonym ]:
(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
Sorbinil
Sorbinilo
Sorbinilum

Chemical & Physical Properties

[ Density]:
1.52g/cm3

[ Molecular Formula ]:
C₁₁H₉FN₂O₃

[ Molecular Weight ]:
236.19900

[ Exact Mass ]:
236.06000

[ PSA ]:
67.43000

[ LogP ]:
1.30050

[ Index of Refraction ]:
1.629

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Articles

The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

PLoS ONE 7(4) , e31399, (2012)

Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase ...

Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.

Invest. Ophthalmol. Vis. Sci. 55(5) , 2853-61, (2014)

Retinal microglia become activated in diabetes and produce pro-inflammatory molecules associated with changes in retinal vasculature and increased apoptosis of retinal neurons and glial cells. We soug...

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.

Chem. Biol. Interact. 234 , 254-60, (2015)

Chronic hyperglycemia is an important risk factor involved in the onset and progression of diabetic retinopathy (DR). Among other effectors, aldose reductase (AR) has been linked to the pathogenesis o...