alpha-2-pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

Names

[ Name ]:
alpha-2-pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

[Synonym ]:
2,8-Bis[trifluoromethyl]-a-(2-pyridyl)-4-quinolinemethanol
(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol
MQ-IS

Chemical & Physical Properties

[ Density]:
1.461g/cm3

[ Boiling Point ]:
422.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₀F₆N₂O

[ Molecular Weight ]:
372.26500

[ Flash Point ]:
209.3ºC

[ Exact Mass ]:
372.07000

[ PSA ]:
46.01000

[ LogP ]:
4.74910

[ Index of Refraction ]:
1.549

MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H413

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-[(tert-butyldimethylsilyl)(2-pyridyl)methoxy]-2,8-bis(trifluoromethyl)quinoline
2,8-Bis(trifluoromethyl)quinolin-4-ol
2-(Chloromethyl)pyridine HCl
4-Bromo-2,8-bis(trifluoromethyl)quinoline

DownStream

bis[2,8-di(trifluoromethyl)quinolin-4-yl-2-pyridyl] ketone
Mefloquine hydrochloride

Articles

High-performance liquid chromatographic separation and extraction investigation for the simultaneous determination of mefloquine and its carboxylic acid metabolite.

J. Chromatogr. A. 427(2) , 295-305, (1988)

Distribution ratios of mefloquine ion pairs with perchlorate and heptanesulphonate as counter-ions, the base distribution for mefloquine, the acid distribution for the carboxylic acid metabolite and t...

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