Isorhyncophylline

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Names

[ CAS No. ]:
6859-01-4

[ Name ]:
Isorhyncophylline

[Synonym ]:
7-Isorhynchophylline
5-Methoxyindole-3-carboxylic Acid Hydrate
7-Isorhyncophylline
5-Methoxyindole-3-Carboxylic Acid
(16E,20α)-17-Methoxy-2-oxocorynox-16-en-16-carboxylic acid
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, (αE,3S,6'R,7'S,8'aS)-
Isorhyncophylline
5-methoxyindole-2-carboxylic acid
1H-Indole-3-carboxylic acid, 5-methoxy-
5-Methoxy-1H-indole-3-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
447.6±25.0 °C at 760 mmHg

[ Melting Point ]:
114ºC

[ Molecular Formula ]:
C22H28N2O4

[ Molecular Weight ]:
384.47

[ Flash Point ]:
224.5±23.2 °C

[ PSA ]:
78.87000

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.677

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN1605000
CHEMICAL NAME :
Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20-alpha)-
CAS REGISTRY NUMBER :
6859-01-4
LAST UPDATED :
198909
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H28-N2-O4
MOLECULAR WEIGHT :
384.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
217 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989

Safety Information

[ Safety Phrases ]:
24/25

Related Compounds

  • Isorhyncophylline
  • Isorhyncophylline
  • 1-(1,4-Dioxaspiro[4.4]nonan-2-ylmethyl)-3-cyclohexylurea
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)-2,4-dimethylbenzenesulfonamide
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)-2-methoxy-5-methylbenzenesulfonamide
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)-3-fluoro-4-methoxybenzenesulfonamide
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)-5-fluoro-2-methoxybenzenesulfonamide
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)-2,5-dichlorobenzenesulfonamide
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)-3-nitrobenzenesulfonamide
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)thiophene-2-sulfonamide
  • 2-Chloro-2-(phenylthio)butanal
  • N-(1,4-dioxaspiro[4.4]nonan-2-ylmethyl)-5-chlorothiophene-2-sulfonamide