H-D-Pyr-OEt

Names

[ Name ]:
H-D-Pyr-OEt

[Synonym ]:
ethyl (2R)-5-oxopyrrolidine-2-carboxylate
Ethyl 5-oxo-D-prolinate
MFCD00010848
D-Proline, 5-oxo-, ethyl ester
H-D-Pyr-OEt

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
312.7±35.0 °C at 760 mmHg

[ Melting Point ]:
49-53ºC

[ Molecular Formula ]:
C₇H₁₁NO₃

[ Molecular Weight ]:
157.167

[ Flash Point ]:
142.9±25.9 °C

[ Exact Mass ]:
157.073898

[ PSA ]:
55.40000

[ LogP ]:
-1.39

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.466

[ Storage condition ]:
2~8°C

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Ethanol
D-Pyroglutamic acid
D(-)-Glutamic acid
D-glutamic acid diethyl ester
diethyl glutamate

DownStream

Ethanol
D-Pyroglutamic acid
(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone
(R)-5-(CHLOROMETHYL)PYRROLIDIN-2-ONE
(3S,7aR)-3-Phenyltetrahydro-5H-pyrrolo[1,2-c][1,3]oxazol-5-one
(3S,7aR)-3-Phenyl-1,7a-dihydro-5H-pyrrolo[1,2-c][1,3]oxazol-5-one

Articles

5-Oxoprolinal: transition-state aldehyde inhibitor of pyroglutamyl-peptide hydrolase.

Biochemistry 24 , 3907, (1985)

Pyroglutamyl-peptide hydrolase (EC 3.4.11.8) removes the N-terminal pyroglutamyl residue from pyroglutamyl-containing peptides such as thyrotropin-releasing hormone (TRH), luteinizing hormone-releasin...

U. Burkard et al.

Liebigs Ann. Chem. , 1030, (1986)

T.P. Andersen et al.

Liebigs Ann. Chem. , 269, (1986)

H-Pyr-OEt
H-D-Asp(OEt)-OEt.HCl
h-d-trp-oet hcl
H-D-Glu-Oet
H-D-Met-OEt *HCl
H-D-CHG-OET HCL
2-(1-Chloro-2-oxopropyl)-4-hydroxybenzoic acid
2-(1-Bromo-2-oxopropyl)-6-hydroxybenzoic acid
(S)-5-Bromo-8-fluorochromane-3-carboxylic acid
(R)-5-Fluoro-8-methylchromane-3-carboxylic acid
1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine-7-carbonitrile
2,2-Difluoro-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid
2-(2,3-Dioxoazepan-1-yl)acetic acid
2-(2-Bromopropanoyl)-4-chlorobenzoic acid
2-(1-Chloro-2-oxopropyl)-5-(hydroxymethyl)benzaldehyde
2-(1-Chloro-2-oxopropyl)-3-(hydroxymethyl)benzaldehyde

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