Sophoridine

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Names

[ Name ]:
Sophoridine

[Synonym ]:
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-
Allomatrine
(5β)-Matridin-15-one
Bio-0637
5-Epidihydrosophocarpine
Dihydro-5-episophocarpine
(7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
sophoridine
matridin-15-one

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
396.7±31.0 °C at 760 mmHg

[ Melting Point ]:
109 °C

[ Molecular Formula ]:
C₁₅H₂₄N₂O

[ Molecular Weight ]:
248.364

[ Flash Point ]:
172.7±17.2 °C

[ Exact Mass ]:
248.188858

[ PSA ]:
23.55000

[ LogP ]:
1.44

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.581

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG1250000

CHEMICAL NAME :: Sophoridine

CAS REGISTRY NUMBER :: 6882-68-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H24-N2-O

MOLECULAR WEIGHT :: 248.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 243 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,153,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YFZADL Yaowu Fenxi Zazhi. Journal of Pharmaceutical Analysis. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981- Volume(issue)/page/year: 6,96,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 350 mg/kg/35D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,153,1987

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

Related Compounds

sophoridine
(-)-sophoridine N-oxide
Ethyl 1-[1-(3-cyano-6-methylquinolin-4-YL)piperidine-4-carbonyl]piperidine-4-carboxylate
3-[2-(3-Fluorophenyl)pyrrolidine-1-carbonyl]-5-methyl-1,2-oxazole
4-Cyclobutylbutanoic acid
N-(2-methylphenyl)-3-(morpholin-4-ylcarbonyl)quinolin-4-amine
(6-Fluoro-4-(o-tolylamino)quinolin-3-yl)(piperidin-1-yl)methanone
(6-Fluoro-4-(m-tolylamino)quinolin-3-yl)(piperidin-1-yl)methanone
(6-Fluoro-4-(p-tolylamino)quinolin-3-yl)(piperidin-1-yl)methanone
(4-((4-Chlorophenyl)amino)-6-fluoroquinolin-3-yl)(piperidin-1-yl)methanone
6-fluoro-N-(2-fluorophenyl)-3-(piperidin-1-ylcarbonyl)quinolin-4-amine
(6-Fluoro-4-((3-fluorophenyl)amino)quinolin-3-yl)(piperidin-1-yl)methanone

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