Cytarabine hydrochloride
Suppliers
Names
[ CAS No. ]:
69-74-9
[ Name ]:
Cytarabine hydrochloride
[Synonym ]:
2(1H)-pyrimidinone, 1-β-D-arabinofuranosyl-3,4-dihydro-4-imino-, hydrochloride (1:1)
Cytosine, 1-β-D-arabino-furanosyl-, hydrochloride
1-b-D-Arabinofuranosylcytosine Monohydrochloride
Cytosine arabinoside hydrochloride
1-(β-D-Arabinofuranosyl)-4-imino-3,4-dihydropyrimidin-2(1H)-one hydrochloride (1:1)
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one hydrochloride
1-β-D-Arabinofuranosylcytosine hydrochloride
Ara-cytidine hydrochloride
4-Amino-1-b-D-arabinofuranosyl-2(1H)-pyrimidinone Monohydrochloride
u 19920a
4-Amino-1-(β-D-arabinofuranosyl)pyrimidin-2(1H)-one hydrochloride (1:1)
MFCD00012839
EINECS 200-713-9
4-Amino-1-(β-D-arabinofuranosyl)-2(1H)-pyrimidinone hydrochloride (1:1)
2(1H)-Pyrimidinone, 4-amino-1-β-D-arabinofuranosyl-, hydrochloride (1:1)
4-amino-1-β-D-arabinofuranosylpyrimidin-2(1H)-one hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
545.7ºC at 760 mmHg
[ Melting Point ]:
197-198 °C(lit.)
[ Molecular Formula ]:
C9H14ClN3O5
[ Molecular Weight ]:
279.678
[ Flash Point ]:
283.8ºC
[ Exact Mass ]:
279.062195
[ PSA ]:
130.83000
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HA5500000
- CHEMICAL NAME :
- Cytosine, 1-beta-D-arabinofuranosyl-, monohydrochloride
- CAS REGISTRY NUMBER :
- 69-74-9
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C9-H13-N3-O5.Cl-H
- MOLECULAR WEIGHT :
- 279.71
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Human
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Primate - monkey
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 826 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 825 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2262 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 172 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 396 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 280 mg/kg
- SEX/DURATION :
- female 15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,85,1988
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H317-H319-H341-H361
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R36;R43;R63
[ Safety Phrases ]:
S26-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
HA5500000
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2942000000
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