3-Benzofurancarboxylic acid, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(Methylsulfonyl)amino]-

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Names

[ CAS No. ]:
691857-54-2

[ Name ]:
3-Benzofurancarboxylic acid, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(Methylsulfonyl)amino]-

[Synonym ]:
HCV 796
5-cyclopropyl-2-(4-fluorophenyl)-6-[N-(2-hydroxyethyl)methanesulfonylamino]benzofuran-3-carboxylic acid methylamide
5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)methanesulfonylamino]benzofuran-3-carboxylic acid methylamide
5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid
5-Cyclopropyl-2-(4-Fluorophenyl)-6-[(2-Hydroxyethyl)(Methylsulfonyl)amino]-N-Methyl-1-Benzofuran-3-Carboxamide
Nesbuvir (USAN)
5-cyclopropyl-2-(4-fluoro-phenyl)-6-methanesulfonylamino-benzofuran-3-carboxylic acid
Nesbuvir

Chemical & Physical Properties

[ Molecular Formula ]:
C19H16FNO5S

[ Molecular Weight ]:
389.39700

[ Exact Mass ]:
389.07300

[ PSA ]:
104.99000

[ LogP ]:
5.33980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl 4-Fluorobenzoylacetate
  • 1,4-Benzoquinone
  • methyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate
  • methyl 2-(4-fluorophenyl)-5-hydroxy-6-nitro-1-benzofuran-3-carboxylate
  • methyl 5-cyclopropyl-2-(4-fluorophenyl)-6-nitro-1-benzofuran-3-carboxylate
  • methyl 2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-1-benzofuran-3-carboxylate

DownStream