Brivudine
Suppliers
Names
[ CAS No. ]:
69304-47-8
[ Name ]:
Brivudine
[Synonym ]:
5-[(E)-2-bromoethenyl]-2'-deoxyuridine
Brivudine
BrVDU
Bromovinyldeoxyuridine
MFCD00058585
5-[(E)-2-Bromovinyl]-2'-deoxyuridine
Zostrex
BVDU
Uridine, 5-[(E)-2-bromoethenyl]-2'-deoxy-
(E)-5-(2-Bromovinyl)-2'-deoxyuridine
BVDR
Chemical & Physical Properties
[ Density]:
1.9±0.1 g/cm3
[ Boiling Point ]:
382.9ºC at 760 mmHg
[ Melting Point ]:
165ºC
[ Molecular Formula ]:
C11H13BrN2O5
[ Molecular Weight ]:
333.135
[ Flash Point ]:
185.4ºC
[ Exact Mass ]:
332.000763
[ PSA ]:
104.55000
[ LogP ]:
-0.80
[ Index of Refraction ]:
1.709
[ Water Solubility ]:
Soluble in water and methanol.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YU7355000
- CHEMICAL NAME :
- Uridine, 5-(2-bromovinyl)-2'-deoxy-, (E)-
- CAS REGISTRY NUMBER :
- 69304-47-8
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C11-H13-Br-N2-O5
- MOLECULAR WEIGHT :
- 333.17
- WISWESSER LINE NOTATION :
- T6NVMVJ E1U1E A- ET5OTJ B1Q CQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1420 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10920 mg/kg/52W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver - other changes Nutritional and Gross Metabolic - changes in chlorine
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Human HeLa cell
- DOSE/DURATION :
- 4 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 267,125,1992
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Safety Phrases ]:
24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YU7355000
Synthetic Route
Articles
Biochem. J. 445(1) , 113-23, (2012)
In the present paper we demonstrate that the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and show that the phosphorol...
Bioorg. Med. Chem. Lett. 18(20) , 5640-2, (2008)
Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of ...
Nucleosides Nucleotides Nucleic Acids 29(1) , 1-13, (2010)
Thymidine kinase 2 (TK2) is a mitochondrial deoxyribonucleoside kinase that phosphorylates several nucleoside analogs used in anti-viral and anti-cancer therapy. A fibroblast cell line with decreased ...