4-Chloro-1,2-difluorobenzene

Names

[ CAS No. ]:
696-02-6

[ Name ]:
4-Chloro-1,2-difluorobenzene

[Synonym ]:
MFCD00042572
4-Chloro-1,2-difluorobenzene
3,4-Difluorochlorobenzene
GR CF DF
Benzene, 4-chloro-1,2-difluoro-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
133.4±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₃ClF₂

[ Molecular Weight ]:
148.538

[ Flash Point ]:
32.5±15.2 °C

[ Exact Mass ]:
147.989136

[ LogP ]:
2.34

[ Vapour Pressure ]:
10.4±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.479

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S16-S26-S36-S37/39

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,2-Difluorobenzene
3-(1-chloro-vinyl)-1,1,2,2-tetrafluoro-cyclobutane
1-chloro-2,2,3,3-tetrafluoro-1-vinyl-cyclobutane
4-Chloro-1-fluoro-2-nitrobenzene
1,4-Dichloro-2-nitrobenzene
5-Chloro-2-fluoroaniline
1,4-Dichlorobenzene
Chlorobenzene

DownStream

1,2-Difluorobenzene
2-(3,4-difluorophenyl)-4,4,6-trimethyl-1,3,2-dioxaborinane
2-Chloro-4,5-difluoroaniline
1,2-difluoro-4-[4-(4-propylcyclohexyl)phenyl]benzene
2-chloro-1-(2-chloro-4,5-difluorophenyl)ethanone
2''-Chloro-4'',5''-difluoroacetophenone
2-Chloro-4,5-difluorobenzoic acid
3,4-difluorophenylboronic acid pinacol ester
1-Chloro-4,5-difluoro-2-nitrobenzene
1,1'-Biphenyl, 3,4-difluoro-

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.

Bioorg. Med. Chem. 16(23) , 9991-10000, (2008)

Optimization of benzoic acid derivatives by introducing substituents into the diphenyl urea moiety led to the identification of compound 20l as a potent VLA-4 antagonist. Compound 20l inhibited eosino...

An investigation of descriptors based on the critical points in the electron density by building quantitative structure-property relationships for proton chemical shifts. Buttingsrud B, et al.

J. Mol. Struct. (Theochem) 810(1) , 15-24, (2007)

4-Chloro-1,2-diamino-3,5-difluorobenzene, 4-Chloro-3,5-difluorophenylene-1,2-diamine
4-Chloro-1,2-benzoxazol-3(2H)-one
4-chloro-1,2-benzothiazol-7-amine
4-chloro-1-(2,5-dichlorophenyl)-2-nitrobenzene
4-chloro-1-(2,5-dichlorophenyl)-2-methylsulfinylbenzene
4-Chloro-1-(2-propyn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
1-(2-Chloro-6-methylpyridin-4-yl)prop-2-en-1-one
3,4-Dimethyl-6-[(methylamino)methyl]cyclohex-3-ene-1-sulfonic acid
Ethyl 1-(2-ethoxyphenyl)-4-hydroxy-1H-pyrazole-3-carboxylate
rac-(3aR,6aR)-N-ethyl-octahydrocyclopenta[c]pyrrole-3a-carboxamide
1-(1-butyl-1H-1,2,3-triazol-5-yl)-2-methoxyethan-1-amine
(1S)-1-[1-(butan-2-yl)-1H-1,2,3-triazol-5-yl]-2-methoxyethan-1-amine
4-[(Oxan-2-yl)methoxy]benzene-1-sulfonyl fluoride
4-(1-Amino-3-hydroxypropan-2-yl)-5-bromo-2-methoxyphenol
3-[(1R)-1-aminopentyl]-7-methyl-7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
(2R,4R)-4-[(4-bromo-5-chloro-2-thienyl)methyl]-1-tert-butoxycarbonyl-pyrrolidine-2-carboxylic acid

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