N-Boc-L-Prolinol

Suppliers

Names

[ Name ]:
N-Boc-L-Prolinol

[Synonym ]:
tert-butyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
tert-butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
(S)-(-)-1-Boc-2-pyrrolidinemethanol
MFCD00066232
N-Boc-L-prolinol
2-Methyl-2-propanyl (2S)-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
Boc-Pro-Ol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
289.5±13.0 °C at 760 mmHg

[ Melting Point ]:
60-64ºC

[ Molecular Formula ]:
C₁₀H₁₉NO₃

[ Molecular Weight ]:
201.26

[ Flash Point ]:
128.9±19.8 °C

[ Exact Mass ]:
201.136490

[ PSA ]:
49.77000

[ LogP ]:
0.46

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.484

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Di-tert-butyl dicarbonate
L-Pro-ol
Boc-L-Proline
Boc-Pro-OMe
Boc-L- Prolinal
(R)-1-Boc-2-[Methoxy(Methyl)carbamoyl]pyrrolidine
Proline
1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S)-
Nα,N,N-tris(tert-butoxycarbonyl)-(S)-prolinamide
(S)-(1-(4-methoxybenzyl)pyrrolidin-2-yl)methanol

DownStream

ABT-239
1-Boc-2-piperidone
O-Methyl-L-prolinol
Boc-L- Prolinal
(4-CHLORO-PYRIMIDIN-2-YL)-ISOPROPYL-AMINE
(S)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97
(S)-2-Bromomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
(S)-TERT-BUTYL 2-(1H-IMIDAZOL-2-YL)PYRROLIDINE-1-CARBOXYLATE
tert-Butyl (S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
(S)-1-Boc-2-(aminomethyl)pyrrolidine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design, synthesis and biological activity of amidinobicyclic compounds (derivatives of DX-9065a) as factor Xa inhibitors: SAR study of S1 and aryl binding sites.

Bioorg. Med. Chem. 12 , 2099-2114, (2004)

Since factor Xa (fXa) plays a pivotal role in the blood coagulation cascade, inhibition of fXa is thought to be an effective treatment for a variety of thrombotic events. (2S)-2-[4-[[(3S)-1-Acetimidoy...

Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.

J. Med. Chem. 39 , 817-825, (1996)

Recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (CNS) disorders as well as the diversity of brain neuronal nicotine a...

Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.

J. Med. Chem. 40 , 385, (1997)

2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine, ABT-089 (S-4), a member of the 3-pyridyl ether class of nicotinic acetylcholine receptor (nAChR) ligands, shows positive effects in rodent and primate mo...

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