trimoprostil

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Names

[ CAS No. ]:
69900-72-7

[ Name ]:
trimoprostil

Chemical & Physical Properties

[ Density]:
1.043g/cm3

[ Boiling Point ]:
528.2ºC at 760 mmHg

[ Molecular Formula ]:
C23H38O4

[ Molecular Weight ]:
378.54500

[ Flash Point ]:
287.3ºC

[ Exact Mass ]:
378.27700

[ PSA ]:
74.60000

[ LogP ]:
5.16240

[ Index of Refraction ]:
1.527

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8010000
CHEMICAL NAME :
Prosta-5,13-dien-1-oic acid, 15-hydroxy-9-oxo-11,16,16-trimethyl-, (5Z,11-alpha,13E,15R)-
CAS REGISTRY NUMBER :
69900-72-7
LAST UPDATED :
199009
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C23-H38-O4
MOLECULAR WEIGHT :
378.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986

Related Compounds

  • Ethyl 3-cyclopropyl-4-formyl-1-methyl-1H-pyrazole-5-carboxylate
  • 4-[5-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]oxypentoxy]benzoic acid
  • Tert-butyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
  • Tert-butyl 2-(4-formylpiperidin-1-yl)pyrimidine-5-carboxylate
  • 4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)piperidine
  • 4'-(4-(Diphenylamino)phenyl)-5'-phenyl-[1,1':2',1''-terphenyl]-4-carbonitrile
  • N-(4-tert-butylcyclohexyl)-N-methylcarbamoyl chloride
  • 2-(Aminomethyl)-1,1,1,4-tetrafluorobutane
  • 2-[(4-Methoxypyridin-2-yl)methyl]-7-[(2-methylimidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-3,4-dihydroisoquinolin-1-one
  • N-(5-methyl-4-{1H-pyrrolo[2,3-b]pyridin-3-yl}-1,3-thiazol-2-yl)-4-(prop-2-enamido)benzamide
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