2-Bromoacetophenone

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Names

[ CAS No. ]:
70-11-1

[ Name ]:
2-Bromoacetophenone

[Synonym ]:
2-Bromo-1-Phenylethan-1-One
α-Bromoacetophenone
MFCD00000195
Phenacyl Bromide
EINECS 200-724-9
Ethanone, 2-bromo-1-phenyl-
2-Bromo-1-phenylethanone
2-Bromoacetophenone

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
253.4±0.0 °C at 760 mmHg

[ Melting Point ]:
48-51 °C(lit.)

[ Molecular Formula ]:
C8H7BrO

[ Molecular Weight ]:
199.045

[ Flash Point ]:
78.4±7.2 °C

[ Exact Mass ]:
197.968018

[ PSA ]:
17.07000

[ LogP ]:
2.19

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.570

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.

[ Water Solubility ]:
PRACTICALLY INSOLUBLE

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R20/21/22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2645 6.1/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • alpha-(bromomethyl)benzyl alcohol
  • phenylene-ethylene
  • (bromoethynyl)benzene
  • Acetophenone
  • (1-Chlorovinyl)benzene
  • ether
  • α-Methylbenzyl bromide
  • Methylbenzylalcohol
  • DIBROMOACETOPHENONE
  • 3',5'-Difluoroacetophenone

DownStream

  • 5-(naphthalen-1-ylmethyl)-3-phenylcyclopent-2-en-1-one
  • ethyl 2-oxo-1-phenacylcyclohexane-1-carboxylate
  • 2-(3,5-diamino-1-phenylpyrazol-4-yl)-1-phenylethanone
  • 4-Phenyl-2-(4-pyridyl)thiazole
  • (2-METHYL-5-PHENYL-3-FURYL)METHANOL
  • 6-chloro-2-methyl-3-(6-phenylimidazo[2,1-b][1,3]thiazol-3-yl)chromen-4-one
  • ethyl 2-amino-5-phenyl-1H-pyrrole-3-carboxylate
  • Phenacyl acetate
  • phenacyl formate
  • Glycolophenone

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

Bioorg. Med. Chem. 23(9) , 2024-34, (2015)

Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[...

Nucleophilic heterocyclic carbene as a novel catalyst for cyclopropanation of cyano acrylates.

Org. Biomol. Chem. 8(4) , 901-5, (2010)

Nucleophilic heterocyclic carbenes (NHCs) have been used for the first time as catalysts in the cyclopropanation of ethyl cyanocinnamates with phenacyl bromide by Michael-initiated ring-closure (MIRC)...

Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates.

Org. Lett. 1(13) , 2117-20, (1999)

[formula: see text] 4'-Bromoacetophenone derivatives which upon excitation can generate monophenyl radicals capable of hydrogen atom abstraction were investigated as photoinducible DNA cleaving agents...


More Articles

Related Compounds

  • 2-Bromoacetophenone
  • 2-bromoacetophenone oxime
  • 4'-iodo-2-bromoacetophenone
  • methoxy-2-bromoacetophenone
  • 4-Amino-2-bromoacetophenone
  • p-nitro-2-bromoacetophenone
  • 4-hydroxy-N-[(5Z)-4-oxo-5-(quinolin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzamide
  • N~2~-{2-[4-(3-chlorophenyl)piperazino]-2-oxoethyl}-1H-indole-2-carboxamide
  • (4-chlorophenyl)[4-(1H-indol-2-ylcarbonyl)piperazin-1-yl]methanone
  • 6-(3,4-Dimethoxybenzyl)-3-(2-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
  • 3-(4-methoxyphenyl)-9-(2-morpholinoethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-2(8H)-one
  • 4-(4-Methylphenylsulphonyloxymethyl)piperidine
  • 3-(3-chloro-1,2-oxazol-5-yl)-N-{2-[(4-methoxyphenyl)carbonyl]-3-methyl-1-benzofuran-6-yl}propanamide
  • (Z)-2-(pyridin-4-ylmethylene)-8-((tetrahydrofuran-2-yl)methyl)-8,9-dihydro-2H-benzofuro[7,6-e][1,3]oxazin-3(7H)-one
  • N-[4-(acetylamino)phenyl]-2-(2-fluorophenyl)-4-methyl-1,3-thiazole-5-carboxamide
  • N-(1,3-benzodioxol-5-yl)-2-[(2Z)-2-{[(4-methoxyphenyl)sulfonyl]imino}-2,3-dihydro-1,3-thiazol-4-yl]acetamide
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