Pentafluoropyridine

Names

[ CAS No. ]:
700-16-3

[ Name ]:
Pentafluoropyridine

[Synonym ]:
Pyridine, 2,3,4,5,6-pentafluoro-
T6NJ BF CF DF EF FF
EINECS 211-839-9
Pentafluoropyridine
2,3,4,5,6-Pentafluoropyridine
Pyridine, pentafluoro-
Perfluoropyridine
MFCD00006225

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
100.1±35.0 °C at 760 mmHg

[ Melting Point ]:
-42

[ Molecular Formula ]:
C₅F₅N

[ Molecular Weight ]:
169.052

[ Flash Point ]:
23.9±0.0 °C

[ Exact Mass ]:
168.995087

[ PSA ]:
12.89000

[ LogP ]:
0.91

[ Vapour Pressure ]:
42.8±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.385

[ Storage condition ]:
Flammables area

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S26-S28-S24/25-S16

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Perchloropyridine
3,5-Dichloro-2,4,6-trifluoropyridine
Pyridine
n-fluoroperfluoropiperidine
Nickel
Iron
trimethyl-(2,3,5,6-tetrafluoropyridin-4-yl)silane
2,2,3,3,4,4,5,5,6-nonafluoropyridine
2-picoline

DownStream

N-(2,3,5,6-tetrafluoropyridin-4-yl)hydroxylamine
3-Fluoropyridine
2,3,5,6-Tetrafluoropyridine
3,5-Difluoropyridine
4-bromo-2,3,5,6-tetrafluoropyridine
2,4,6-tribromo-3,5-difluoropyridine
4-Chloro-2,3,5,6-tetrafluoropyridine
3,4-Dichloro-2,5,6-trifluoropyridine
3,4,5-trichloro-2,6-difluoropyridine
3-Chlorotetrafluoropyridine

Articles

Solid phase analytical derivatization of anthropogenic and natural phenolic estrogen mimics with pentafluoropyridine for gas chromatography-mass spectrometry.

J. Chromatogr. A. 1218(51) , 9135-41, (2011)

A simple, low cost, fast and sensitive method is reported for the determination of the four endocrine disrupting chemicals (EDCs) 4-tert-butylphenol, 4-tert-octylphenol, bisphenol A and 17β-estradiol ...

Photochemical Reactions of Fluorinated Pyridines at Half-Sandwich Rhodium Complexes: Competing Pathways of Reaction.

Organometallics 33(1) , 45-52, (2014)

Irradiation of CpRh(PMe3)(C2H4) (1; Cp = _(5)-C5H5) in the presence of pentafluoropyridine in hexane solution at low temperature yields an isolable _(2)-C,C-coordinated pentafluoropyridine complex, Cp...

Palladium-catalyzed coupling reaction of perfluoroarenes with diarylzinc compounds.

Chemistry 20(7) , 2040-8, (2014)

This report describes the first Pd(0)-catalyzed cross-coupling of hexafluorobenzene (C6F6) with diarylzinc compounds to give a variety of pentafluorophenyl arenes. This reaction could be applied to ot...