5-Fluoro-2,3-dihydro-1H-inden-1-one

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Names

[ CAS No. ]:
700-84-5

[ Name ]:
5-Fluoro-2,3-dihydro-1H-inden-1-one

[Synonym ]:
5-fluoro-2,3-dihydro-1H-inden-1-one
5-Fluor-2,3-dihydro-1H-inden-1-on
5-Fluoro-1-indanone
MFCD00041031
1H-Inden-1-one, 5-fluoro-2,3-dihydro-
5-fluoroindan-1-one
5-fluoro-2,3-dihydroinden-1-one

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
247.0±29.0 °C at 760 mmHg

[ Melting Point ]:
35-39ºC

[ Molecular Formula ]:
C9H7FO

[ Molecular Weight ]:
150.150

[ Flash Point ]:
87.2±14.5 °C

[ Exact Mass ]:
150.048096

[ PSA ]:
17.07000

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.560

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-(3-Fluorophenyl)propanoic acid
  • p-Fluoro-β-chloropropiophenone
  • 3-Fluorobenzaldehyde
  • (2E)-3-(3-Fluorophenyl)acrylic acid
  • Benzenepropanoyl chloride, 3-fluoro-
  • Fluorobenzene
  • Propanedioic acid,2-[(3-fluorophenyl)methyl]-, 1,3-diethyl ester
  • 3-(3-fluorophenyl)acrylic acid methyl ester

DownStream

  • 2-BROMO-2,3-DIHYDRO-5-FLUORO-1H-INDEN-1-ONE
  • 5-Fluoro-2,3-dihydro-1H-inden-2-amine
  • 6-Fluoro-1,2,3,4-tetrahydro-isoquinoline
  • 6-FLUORO-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE
  • 5-MORPHOLIN-4-YL-INDAN-1-ONE
  • 5-(Piperidin-1-yl)-2,3-dihydro-1H-inden-1-one
  • 1-Cyclopropyl-5-fluoroindan-1-ol
  • 5-(4-METHYL-PIPERAZIN-1-YL)-INDAN-1-ONE
  • 7-fluoro-3,4,4a,5-tetrahydro-2H-indeno[1,2-b]pyridine
  • 2,3-DIHYDRO-5-FLUORO-1H-INDENE-1-CARBOXYLIC ACID

Articles

Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents.

Bioorg. Med. Chem. 19(22) , 6818-26, (2011)

In the present work, we synthesized a series of thiosemicarbazones derived from 1-indanones with good anti-Trypanosoma cruzi activity. Most of them displayed remarkable trypanosomicidal activity. All ...

Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.

Bioorg. Med. Chem. 16(17) , 7956-67, (2008)

We have previously reported on antitussive effect of (5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5',6'-dihydro-3-methoxy-4'H-pyrrolo[3,2,1-ij]quinolino[2',1':6,7]morphinan-14-ol(1b) m...


More Articles

Related Compounds

  • 5-fluoro-2,3-dihydro-1H-inden-1-one
  • 4-bromo-5-fluoro-2,3-dihydro-1H-inden-1-one
  • 7-Bromo-5-fluoro-2,3-dihydro-1H-inden-1-one
  • 6-Bromo-5-fluoro-2,3-dihydro-1H-inden-1-one
  • 6-chloro-5-fluoro-2,3-dihydro-1H-inden-1-one
  • 5-fluoro-2,3-dihydro-1H-inden-1-amine,hydrochloride
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • n-Hydroxy-2-(naphthalene-2-sulfonylamino)-acetamide
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • rac-(3aR,4R,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-4-ol