Cimetidine hydrochloride

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Names

[ CAS No. ]:
70059-30-2

[ Name ]:
Cimetidine hydrochloride

[Synonym ]:
EINECS 274-297-2
MFCD01724314
Cimetidin-HCl
Cimetidine Hydrochloride USP24
Cimetidinhydrochlorid
cimetex
Cimetidine hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
488ºC at 760 mmHg

[ Molecular Formula ]:
C10H17ClN6S

[ Molecular Weight ]:
288.80000

[ Flash Point ]:
248.9ºC

[ Exact Mass ]:
288.09200

[ PSA ]:
114.19000

[ LogP ]:
2.18118

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF0035100
CHEMICAL NAME :
Guanidine, N-cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl )methyl)thio)ethyl)-, monohydrochloride
CAS REGISTRY NUMBER :
70059-30-2
LAST UPDATED :
199504
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H16-N6-S.Cl-H
MOLECULAR WEIGHT :
288.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
12 mg/kg/6H-I
TOXIC EFFECTS :
Blood - leukopenia Blood - thrombocytopenia

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
500 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,833,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3086 No. of Facilities: 485 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 17435 (estimated) No. of Female Employees: 14362 (estimated)

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
MF0035100

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pharmacokinetic study of hydroxypropylmethylcellulose microparticles loaded with cimetidine.

Adv. Clin. Exp. Med. 22(1) , 41-5, (2013)

The objective of this study was to assess the pharmacokinetic behavior of floating hydroxypropylmethylcellulose microparticles loaded with cimetidine (FMC) prepared using the non-solvent addition coac...

Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2.

Am. J. Physiol. Renal Physiol. 304(1) , F56-67, (2013)

OCT2 is the entry step for organic cation (OC) secretion by renal proximal tubules. Although many drugs inhibit OCT2 activity, neither the mechanistic basis of their inhibition nor their transport sta...

Inhibition of human alcohol and aldehyde dehydrogenases by cimetidine and assessment of its effects on ethanol metabolism.

Chem. Biol. Interact. 202(1-3) , 275-82, (2013)

Previous studies have reported that cimetidine, an H2-receptor antagonist used to treat gastric and duodenal ulcers, can inhibit alcohol dehydrogenases (ADHs) and ethanol metabolism. Human alcohol deh...


More Articles

Related Compounds

  • Cimetidine Hydrochloride USP24
  • cimetidine dihydrochloride imp d
  • carnitine hydrochloride
  • Triprolidine hydrochloride
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  • 5-bromo-2-ethoxy-N-(4-(imidazo[2,1-b]thiazol-6-yl)phenyl)benzenesulfonamide
  • N-tert-butyl-1-(2-cyanophenyl)methanesulfonamide
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  • CID 26985068
  • [(1-Cyano-1,2-dimethylpropyl)carbamoyl]methyl 3-(1,3-benzothiazol-2-yl)pyrazine-2-carboxylate
  • N-(2,4-Difluorophenyl)-Na(2)-[(3,5-dimethoxyphenyl)(1-methyl-1H-imidazol-2-yl)methyl]urea
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