Galunisertib (LY2157299)

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Names

[ CAS No. ]:
700874-72-2

[ Name ]:
Galunisertib (LY2157299)

[Synonym ]:
2-(6-Methyl-pyridin-2-yl)-1-quinoxalin-6-yl-ethanone
4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
2-(6-methyl-pyridin-2-yl)-3-(6-amido-quinolin-4-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole
LY2157299
LY-2157299
LY 2157299
6-Quinolinecarboxamide, 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-
Galunisertib
4-[2-(6-Methyl-2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
6-[2-(6-Methylpyridin-2-yl)-acetyl]quinoxaline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
619.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H19N5O

[ Molecular Weight ]:
369.419

[ Flash Point ]:
328.2±31.5 °C

[ Exact Mass ]:
369.158966

[ PSA ]:
86.69000

[ LogP ]:
1.73

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.751

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25

[ Safety Phrases ]:
45

[ HS Code ]:
29334900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • METHYL 4-(2-(6-METHYLPYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL-3-YL)QUINOLINE-6-CARBOXYLATE

DownStream

  • 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide,hydrate

Related Compounds

  • LY2157299
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-Chloro-5-iodo-1,3,4-trimethylbenzene
  • tert-Butyl-DL-alanine
  • 2-(5-Phenylthiophen-2-yl)morpholine