Pimonidazole

Suppliers

Names

[ Name ]:
Pimonidazole

[Synonym ]:
1-Piperidineethanol, α-[(2-nitro-1H-imidazol-1-yl)methyl]-
Pimonidazol
(±)-a-[(2-nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
UNII:46JO4D76R2
Pimonidazole [INN:BAN]
Pimonidazole
Pimonidazol [Spanish]
1-(2-nitro-imidazol-1-yl)-3-piperidin-1-yl-propan-2-ol
1-(2-Nitro-1H-imidazol-1-yl)-3-(1-piperidinyl)-2-propanol
(±)-α-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol
1-(2-nitroimidazol-1-yl)-3-(1-piperidinyl)-2-propanol
1-(2-Nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol
Pimonidazolum
Ro 03-8799
Pimonidazolum [Latin]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
490.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₈N₄O₃

[ Molecular Weight ]:
254.286

[ Flash Point ]:
250.5±31.5 °C

[ Exact Mass ]:
254.137894

[ PSA ]:
87.11000

[ LogP ]:
1.00

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.642

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Loss of the Notch effector RBPJ promotes tumorigenesis.

J. Exp. Med. 212(1) , 37-52, (2015)

Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation ...

Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension.

Microcirculation 22 , 724-736, (2016)

Myocardial angiogenesis is presumed to play a role in RV adaptation to PH, though definitive evidence and functional correlations are lacking. We aimed to use definitive methods to correlate RV angiog...

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling.

Oncotarget 5(20) , 9664-77, (2014)

Hypoxia is a common phenomenon occurring in the majority of human tumors and has been proved to play an important role in tumor progression. However, it remains unclear that whether the action of hypo...