2H-1,3-Oxazine-2,4(3H)-dione,5,5-diethyldihydro-

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Names

[ CAS No. ]:
702-54-5

[ Name ]:
2H-1,3-Oxazine-2,4(3H)-dione,5,5-diethyldihydro-

[Synonym ]:
Dietadione [Italian]
Diethadione
Dioxone
Persisten
5,5-diethyldihydro-2H-1,3-oxazine-2,4(3H)-dione
5,5-Diaethyl-dihydro-[1,3]oxazin-2,4-dion
Toce
5,5-diethyl-[1,3]oxazinane-2,4-dione
DIETHADION
Tocen
Lepton
Ledosten
Dietroxin
5,5-diethyl-dihydro-[1,3]oxazine-2,4-dione

Chemical & Physical Properties

[ Density]:
1.069g/cm3

[ Molecular Formula ]:
C8H13NO3

[ Molecular Weight ]:
171.19

[ Exact Mass ]:
171.09000

[ PSA ]:
55.40000

[ LogP ]:
1.38800

[ Index of Refraction ]:
1.44

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6300000
CHEMICAL NAME :
2H-1,3-Oxazine-2,4(3H)-dione, 5,5-diethyldihydro-
CAS REGISTRY NUMBER :
702-54-5
BEILSTEIN REFERENCE NO. :
0133129
LAST UPDATED :
199701
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C8-H13-N-O3
MOLECULAR WEIGHT :
171.22
WISWESSER LINE NOTATION :
T6OVMVTJ E2 E2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 13,244,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 13,244,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 13,244,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,282,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,281,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
61 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,281,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 13,244,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,282,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4550 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Related to Chronic Data - death
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 13,244,1961

Related Compounds

  • 2H-1,3-Oxazine-2,4(3H)-dione, 5-acetyl-6-methyl- (9CI)
  • 2H-1,3-Oxazine-2,4(3H)-dione,dihydro-3-hydroxy-5,5-diphenyl-
  • 5,6-Dihydro-3-methyl-5,5-dipropyl-2H-1,3-oxazine-2,4(3H)-dione
  • 5,6-dimethyl-1,3-oxazine-2,4-dione
  • 5,5-dibutyl-3-methyl-1,3-oxazinane-2,4-dione
  • 2H-1,3-Oxazine-2,4(3H)-dione,6-ethyldihydro-3-(2-hydroxyethyl)-5-(1-methylethyl)-,(5R,6S)-rel-(9CI)
  • N-(6-bromopyridine-2-yl)-4-(trifluoromethyl)pyridine-2-amine
  • 4-Cyano-2,3-difluorobenzoyl chloride
  • Tert-butyl 4-chloro-3-formyl-1-methylcyclohex-3-ene-1-carboxylate
  • 4-[[(3S)-1-(2-Fluoroethyl)-3-pyrrolidinyl]amino]-3-nitrobenzenesulfonamide
  • 6-Chloro-2,8-dimethylimidazo[1,2-a]pyridin-3-amine
  • (1,1-Difluoroprop-2-yn-1-yl)benzene
  • 6-Cyano-N-(pyridin-4-ylmethyl)pyridine-3-sulfonamide
  • 3-Amino-6-bromo-8-methylimidazo[1,2-a]pyridine
  • 2,2-difluoro-2-(1-methyl-1H-indol-3-yl)acetic acid
  • 5-(3-Azabicyclo[3.1.0]hexan-2-yl)thiazole