Methoxy(phenyl)acetic acid

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Names

[ Name ]:
Methoxy(phenyl)acetic acid

[Synonym ]:
Methoxy(phenyl)acetic acid
EINECS 230-300-9
α-methoxy-α-phenylacetic acid
α-Methoxybenzeneacetic acid
DL-α-Methoxyphenylacetic acid
Benzeneacetic acid, α-methoxy-
(±)-α-Methoxyphenylacetic acid
MFCD00064217

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
283.8±0.0 °C at 760 mmHg

[ Melting Point ]:
68-72ºC

[ Molecular Formula ]:
C₉H₁₀O₃

[ Molecular Weight ]:
166.174

[ Flash Point ]:
116.1±15.3 °C

[ Exact Mass ]:
166.062988

[ PSA ]:
46.53000

[ LogP ]:
1.29

[ Appearance of Characters ]:
crystalline | white

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.535

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Mandelic acid
Dimethyl sulfate
ethyl α-methoxy-α-phenylacetate
2-Bromo-2-phenylacetic acid
Sodium Methylate
2,2,2-Trichloro-1-phenylethanol
Methanol
Phenylacetylene
Benzeneacetic acid, a-methoxy-, methyl ester

DownStream

(2S)-Methoxy(phenyl)acetic acid
Guaiacol acetate
(R)-(-)-2-Methoxy-2-phenylethanol
N-{5-[Methoxy(phenyl)acetyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyra zol-3-yl}-4-(4-methyl-1-piperazinyl)benzamide
Benzeneacetic acid, a-methoxy-, methyl ester
methyl cyclohexaneacetate
cyclohexyl-methoxy-acetic acid methyl ester
1,3-dimethoxy-1-phenylpropan-2-one
Methoxyphenylacetic acid
2-Methoxy-2-phenylethanol

Articles

Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.

ChemBioChem. 16(6) , 924-9, (2015)

A meso-diaminopimelate dehydrogenase (DAPDH) from Clostridium tetani E88 (CtDAPDH) was found to have low activity toward the D-amino acids other than its native substrate. Site-directed mutagenesis si...

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Bioorg. Med. Chem. 22(17) , 4968-97, (2014)

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led t...

Capsule Switching and Antimicrobial Resistance Acquired during Repeated Streptococcus pneumoniae Pneumonia Episodes.

J. Clin. Microbiol. 53 , 3318-24, (2015)

Streptococcus pneumoniae colonizes the nasopharyngeal mucus in healthy people and causes otitis media, pneumonia, bacteremia, and meningitis. In this study, we analyzed an S. pneumoniae strain that ca...

(2S)-Methoxy(phenyl)acetic acid
(2S)-Methoxy(phenyl)acetic acid
methoxy-phenyl-acetic acid [(3Z)-2-oxo-1,2-dihydro-indol-3-ylidene]-hydrazide
(3-methoxy-phenyl)-acetic acid-anhydride
(2-Methoxy-phenyl)-acetic acid ethoxycarbonylmethyl ester
(4-methoxy-phenyl)-acetic acid-(4-benzyloxy-3-methoxy-phenethylamide)
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
3-Amino-3-cyclopropylpropane-1,2-diol
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide