Methoxy(phenyl)acetic acid

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Names

[ CAS No. ]:
7021-09-2

[ Name ]:
Methoxy(phenyl)acetic acid

[Synonym ]:
Methoxy(phenyl)acetic acid
EINECS 230-300-9
α-methoxy-α-phenylacetic acid
α-Methoxybenzeneacetic acid
DL-α-Methoxyphenylacetic acid
Benzeneacetic acid, α-methoxy-
(±)-α-Methoxyphenylacetic acid
MFCD00064217

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
283.8±0.0 °C at 760 mmHg

[ Melting Point ]:
68-72ºC

[ Molecular Formula ]:
C9H10O3

[ Molecular Weight ]:
166.174

[ Flash Point ]:
116.1±15.3 °C

[ Exact Mass ]:
166.062988

[ PSA ]:
46.53000

[ LogP ]:
1.29

[ Appearance of Characters ]:
crystalline | white

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.535

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Precursor & DownStream

Precursor

  • Mandelic acid
  • Dimethyl sulfate
  • ethyl α-methoxy-α-phenylacetate
  • 2-Bromo-2-phenylacetic acid
  • Sodium Methylate
  • 2,2,2-Trichloro-1-phenylethanol
  • Methanol
  • Phenylacetylene
  • Benzeneacetic acid, a-methoxy-, methyl ester

DownStream

  • (2S)-Methoxy(phenyl)acetic acid
  • Guaiacol acetate
  • (R)-(-)-2-Methoxy-2-phenylethanol
  • N-{5-[Methoxy(phenyl)acetyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyra zol-3-yl}-4-(4-methyl-1-piperazinyl)benzamide
  • Benzeneacetic acid, a-methoxy-, methyl ester
  • methyl cyclohexaneacetate
  • cyclohexyl-methoxy-acetic acid methyl ester
  • 1,3-dimethoxy-1-phenylpropan-2-one
  • Methoxyphenylacetic acid
  • 2-Methoxy-2-phenylethanol

Articles

Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.

ChemBioChem. 16(6) , 924-9, (2015)

A meso-diaminopimelate dehydrogenase (DAPDH) from Clostridium tetani E88 (CtDAPDH) was found to have low activity toward the D-amino acids other than its native substrate. Site-directed mutagenesis si...

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Bioorg. Med. Chem. 22(17) , 4968-97, (2014)

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led t...

Capsule Switching and Antimicrobial Resistance Acquired during Repeated Streptococcus pneumoniae Pneumonia Episodes.

J. Clin. Microbiol. 53 , 3318-24, (2015)

Streptococcus pneumoniae colonizes the nasopharyngeal mucus in healthy people and causes otitis media, pneumonia, bacteremia, and meningitis. In this study, we analyzed an S. pneumoniae strain that ca...


More Articles


Related Compounds

  • (2S)-Methoxy(phenyl)acetic acid
  • (2S)-Methoxy(phenyl)acetic acid
  • methoxy-phenyl-acetic acid [(3Z)-2-oxo-1,2-dihydro-indol-3-ylidene]-hydrazide
  • (3-methoxy-phenyl)-acetic acid-anhydride
  • (2-Methoxy-phenyl)-acetic acid ethoxycarbonylmethyl ester
  • (4-methoxy-phenyl)-acetic acid-(4-benzyloxy-3-methoxy-phenethylamide)