BUCINDOLOL

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Names

[ CAS No. ]:
70369-47-0

[ Name ]:
BUCINDOLOL

[Synonym ]:
o-(2-Hydroxy-3-((2-indol-3-yl-1,1-dimethylethyl)amino)propoxy)benzonitrile monohydrochloride
Bucindolol HCl
Bucindolol hydrochloride
Benzonitrile,2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl)amino)propoxy)-,monohydrochloride
2-(2-Hydroxy-3-((2-(3-indolyl)-1,1-dimethylethyl)amino)propoxy)benzonitrile hydrochloride
Bucindolol hydrochloride (USAN)

Chemical & Physical Properties

[ Boiling Point ]:
605.3ºC at 760 mmHg

[ Molecular Formula ]:
C22H25N3O2

[ Molecular Weight ]:
363.45300

[ Flash Point ]:
319.9ºC

[ Exact Mass ]:
363.19500

[ PSA ]:
81.07000

[ LogP ]:
3.78108

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DI4605000
CHEMICAL NAME :
Benzonitrile, 2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl) amino)propoxy)-, monohydrochloride
CAS REGISTRY NUMBER :
70369-47-0
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H25-N3-O2.Cl-H
MOLECULAR WEIGHT :
399.96

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,1,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,1,1983

Related Compounds

  • Bucindolol
  • DL-BUCINDOLOL HCL
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1-methyl-3-{3-[(1H-pyrazol-1-yl)methyl]azetidin-1-yl}-1,2-dihydropyrazin-2-one
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyano-2-methoxy-1-methylethyl)-2,3-dihydro-1H-indene-1-carboxamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine