Azirino[2',3'_3,4]pyrrolo[1,2-.α.]indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-hydroxy-8-(hydroxymethyl)-8a-methoxy-5-methyl-, 8-carbamate

Names

[ CAS No. ]:
7041-61-4

[ Name ]:
Azirino[2',3'_3,4]pyrrolo[1,2-.α.]indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-hydroxy-8-(hydroxymethyl)-8a-methoxy-5-methyl-, 8-carbamate

[Synonym ]:
7-demethylmitomycin A
N-[2-(7-hydroxy-naphthalen-1-yl)ethyl]acetamide
N-[2-(7-hydroxy-naphth-1-yl)ethyl]acetamide
7-Demethyl-Agomelatine
7-hydroxymitosane
7-hydroxy-9a-methoxymitosane
N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Boiling Point ]:
512.1ºC at 760 mmHg

[ Molecular Formula ]:
C15H17N3O6

[ Molecular Weight ]:
335.31200

[ Flash Point ]:
263.5ºC

[ Exact Mass ]:
335.11200

[ PSA ]:
141.10000

[ Index of Refraction ]:
1.683

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CN0880000
CAS REGISTRY NUMBER :
7041-61-4
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H17-N3-O6
MOLECULAR WEIGHT :
335.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 20,72,1967

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Mitomycin C
  • Mitomycin A

DownStream

  • 7-(2-hydroxyethoxy)mitosane
  • Mitomycin A
  • brn 4771482

Related Compounds

  • Tert-butyl 3-amino-3-(oxolan-2-yl)piperidine-1-carboxylate
  • 1-[(1-Amino-4,4-difluorocyclohexyl)methyl]-3-propylurea
  • methyl 5-(1H-1,2,4-triazol-3-yl)-1H-1,2,3-triazole-4-carboxylate
  • methyl 5-(pyridazin-3-yl)-1H-1,2,3-triazole-4-carboxylate
  • Tert-butyl 3-(thian-2-yl)prop-2-ynoate
  • 5-(butan-2-yl)-4-(propan-2-yl)-4H-1,2,4-triazole-3-sulfonyl fluoride
  • 5-(azetidin-3-yl)-4-cyclopropyl-4H-1,2,4-triazole-3-sulfonyl fluoride
  • (Butan-2-yl)({[4-(2-methoxyethyl)oxan-4-yl]methyl})amine
  • 1-(2-Methylbut-3-yn-2-yl)-4-(2-methylpropyl)piperazine
  • 2-[(2-Methylpiperidin-1-yl)methyl]cyclopropane-1-carboxylic acid
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