CHLORPHENAMINE MALEATES

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Names

[ CAS No. ]:
7054-11-7

[ Name ]:
CHLORPHENAMINE MALEATES

[Synonym ]:
chlorphenamine maleate
chloropheniramine maleate
chlortrimeton

Chemical & Physical Properties

[ Melting Point ]:
130-135ºC(lit.)

[ Molecular Formula ]:
C₂₀H₂₃ClN₂O₄

[ Molecular Weight ]:
390.86100

[ Exact Mass ]:
390.13500

[ PSA ]:
90.73000

[ LogP ]:
3.14170

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US6503000

CAS REGISTRY NUMBER :: 7054-11-7

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H19-Cl-N2.C4-H4-O4

MOLECULAR WEIGHT :: 390.90

WISWESSER LINE NOTATION :: T6NJ BYR DG&2N1&1 &QV1U1VQ -+-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 121 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 500 umol/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994

Safety Information

[ Hazard Codes ]:
T,Xi

[ Risk Phrases ]:
25-36/37/38

[ Safety Phrases ]:
36/37/39-45-36-26

[ RIDADR ]:
UN 2811 6.1/PG 3

Related Compounds

CHLORPHENAMINE MALEATES
Chlorpheniramine
Desmethyl Chlorpheniramine Maleate Salt
Chlorpheniramine Nitrile
3-(4-chlorophenyl)-3-pyridin-2-yl-N,N-bis(trideuteriomethyl)propan-1-amine
N-desmethylchlorpheniramine
Pyridine, 2-methoxy-3-nitro-6-[3-(trifluoromethoxy)phenyl]-
6,10-Dodecadien-1-yn-3-ol-1,2-13C2, 3,7,11-trimethyl-, (E)-
2-(2-Bromo-3-oxo-3-phenylpropyl)-1H-isoindole-1,3(2H)-dione
2,3-Dihydro-N-(3-hydroxypropyl)-1,4-benzodioxin-2-acetamide
N-[(3-Chlorophenyl)sulfonyl]glycine 1,1-dimethylethyl ester
(I+/-S)-2-Methoxy-I+/--methyl-4-(4-morpholinyl)benzenemethanamine
D-Isovaline, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-
1-Butoxy-2,3-difluoro-4-(4-pentyl-1-cyclohexen-1-yl)benzene
1,3-Propanediol, 2-(4-morpholinylmethyl)-2-(phenoxymethyl)-
I(2),I(2)3-Diamino-2-hydroxy-5-methyl-1,3-benzenedipropanoic acid

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