Daurisoline

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Names

[ Name ]:
Daurisoline

[Synonym ]:
7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-hydroxy-3-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-, (1R)-
(1R)-1-[3-(4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}phenoxy)-4-hydroxybenzyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinol
(1R)-1-[3-(4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenoxy)-4-hydroxybenzyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
724.5±60.0 °C at 760 mmHg

[ Melting Point ]:
96-102ºC

[ Molecular Formula ]:
C₃₇H₄₂N₂O₆

[ Molecular Weight ]:
610.739

[ Flash Point ]:
392.0±32.9 °C

[ Exact Mass ]:
610.304260

[ PSA ]:
83.86000

[ LogP ]:
5.84

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
?20°C

[ Water Solubility ]:
DMSO: soluble15mg/mL, clear

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5995000

CHEMICAL NAME :: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxy-3-(4-((1,2,3,4-tetra hydro-6,7-dimethoxy-2- methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)- 6-methoxy-2-methyl-, (R-(R*,R*))-

CAS REGISTRY NUMBER :: 70553-76-3

LAST UPDATED :: 198103

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C37-H42-N2-O6

MOLECULAR WEIGHT :: 610.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 14,439,1979

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NX5995000

Articles

Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs.

Acta Pharmacol. Sin. 24(10) , 1011-5, (2003)

To study the combined pharmacokinetic-pharmacodynamic (PK-PD) model of daurisoline and dauricine, and compare their effects on cardiac electrophsiology, blood pressure, and hemodynamics in beagle dogs...

Effects of daurisoline on intracellular Ca2+ activity in myocardium.

Zhongguo Yao Li Xue Bao 17(3) , 248-51, (1996)

To explain the effect of daurisoline (DS) on delayed afterdepolarization (DAD).Ca(2+)-sensitive microelectrode technic was used to record intracellular Ca2+ activity (alpha Cai) and triggered activity...

Effects of the putative P-type calcium channel blocker, R,R-(-)-daurisoline on neurotransmitter release.

Naunyn Schmiedebergs Arch. Pharmacol. 352(6) , 670-8, (1995)

The alkaloid and medicinal herb constituent, R,R-(-)-daurisoline, was originally reported to be a N-type Ca2+ channel blocker, but newer evidence indicates that it is a blocker of P-type Ca2+ channels...

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