ornoprostil

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Names

[ CAS No. ]:
70667-26-4

[ Name ]:
ornoprostil

[Synonym ]:
Ornoprostilum [Latin]
6-Oxo-17(S),20-dimethyl-PGE(1)-methylester
(17S)-17,20-dimethyl-6-oxo-PGE1 methyl ester
Ornoprostilo [Spanish]
ornoprostil
Ornoprostilum
Ornoprostilo
Ronoprost

Chemical & Physical Properties

[ Density]:
1.112g/cm3

[ Boiling Point ]:
549.8ºC at 760 mmHg

[ Molecular Formula ]:
C23H38O6

[ Molecular Weight ]:
410.54

[ Flash Point ]:
178.8ºC

[ Exact Mass ]:
410.26700

[ PSA ]:
100.90000

[ LogP ]:
3.37860

[ Index of Refraction ]:
1.526

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8370000
CHEMICAL NAME :
Prost-13-en-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-6,9-dioxo-, methyl ester, (11-alpha,13E)-
CAS REGISTRY NUMBER :
70667-26-4
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C23-H38-O6
MOLECULAR WEIGHT :
410.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,249,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,249,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,249,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,249,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
43500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,249,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,249,1990

Synthetic Route

Precursor & DownStream

Precursor

  • 6-trimethylsilylhex-5-ynoic acid
  • Methyl 6-bromohexanoate
  • methyl 6-nitrohept-6-enoate
  • methyl 6-nitrohexanoate
  • methyl 7-hydroxy-6-nitroheptanoate

DownStream


Related Compounds

  • ornoprostil
  • ornoprostil
  • Ornoprostil bis-tert-butyldimethylsiloxy ether