1,4-BIS((2-((2-HYDROXYETHYL)AMINO)ETHYL) AMINO)-9,10-ANTHRACENEDIONE DIACETATE
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Names
[ CAS No. ]:
70711-40-9
[ Name ]:
1,4-BIS((2-((2-HYDROXYETHYL)AMINO)ETHYL) AMINO)-9,10-ANTHRACENEDIONE DIACETATE
[Synonym ]:
Ametantrone acetate (usan)
Ametantrone acetate
Chemical & Physical Properties
[ Boiling Point ]:
708.8ºC at 760mmHg
[ Molecular Formula ]:
C24H32N4O6
[ Molecular Weight ]:
472.53400
[ Flash Point ]:
382.4ºC
[ Exact Mass ]:
472.23200
[ PSA ]:
160.02000
[ LogP ]:
1.46830
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CB5748300
- CHEMICAL NAME :
- Anthraquinone, 1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-, diacetate
- CAS REGISTRY NUMBER :
- 70711-40-9
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C22-H28-N4-O4.2C2-H4-O2
- MOLECULAR WEIGHT :
- 532.66
- WISWESSER LINE NOTATION :
- T C666 BV IVJ DM2M2Q GM2M2Q &QV1 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 495 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 62830 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 297 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 34 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 21650 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 5200 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 10 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,2574,1979